| Name | PPARBP |
|---|---|
| Description | PPAR binding protein |
| Owner | Public |
| URN | urn:agi-llid:5469 |
| Connectivity | 26 |
| Notes | The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. DRIP205 coactivation of estrogen receptor alpha (ERalpha) involves multiple domains of both proteins. DRIP205 has a role as a coactivator of FXR. Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation. RB18A plays a central role to control p53wt and p53mut protein content and functions in cells through a loop of regulation, which involves MDM2. TFIID and human mediator coactivator (TRAP220) complexes assemble cooperatively on promoter DNA. TRAP220 complex play an important role as putative co-activator complexes in BRCA1-mediated tumor suppression. Examination of regulation by cellular signaling pathways. Extended LXXLL motif sequence determines the nuclear receptor binding specificity. Regulates p53-dependent apoptosis. Spermine significantly enhanced the interaction between HNF4alpha and full-length DRIP205 in an AF-2, NR-box-dependent manner. Spermine enhanced the interaction of DRIP205 with the VDR , but decreased the interaction of both HNF4alpha and VDR with GRIP1. There is a coregulatory role for subunits of this protein in androgen receptor-mediated gene expression. |
| Microarray ID | 102757_at |
|---|---|
| 1450402_at | |
| 1453972_x_at | |
| 160603_at | |
| 115170_at | |
| 1448708_at | |
| 102174_f_at | |
| 1415950_a_at | |
| 1438649_x_at | |
| 162299_f_at | |
| 93124_at | |
| msa.23387.0_s_at | |
| msa.9041.0_f_at | |
| u43206_s_at | |
| A_51_P324082 | |
| A_52_P176300 | |
| A_65_P07232 | |
| A_51_P171700 | |
| A_51_P171697 | |
| A_52_P520439 | |
| 225456_at | |
| 225452_at | |
| 32064_at | |
| 56136_at | |
| 44549_at | |
| 203496_s_at | |
| 203497_at | |
| H40732_at | |
| RC_AA151593_at | |
| RC_AA281949_at | |
| l40366_at | |
| rc_aa453404_at | |
| rc_r44709_at | |
| A_23_P425704 | |
| A_14_P133898 | |
| A_14_P138692 | |
| A_24_P940666 | |
| OH2689 | |
| SC424 | |
| 1421906_at | |
| 1421907_at |
| Chromosome position | 11 61.0 cM |
|---|---|
| 17q12-q21.1 |
| GO ID | 0000119 |
|---|---|
| 0003677 | |
| 0004872 | |
| 0005634 | |
| 0006350 | |
| 0006355 | |
| 0006367 | |
| 0016455 | |
| 0016563 | |
| 0030374 | |
| 0030521 | |
| 0042809 | |
| 0046966 | |
| 0001701 | |
| 0001747 | |
| 0001889 | |
| 0001892 | |
| 0003682 | |
| 0003713 | |
| 0005515 | |
| 0006260 | |
| 0006366 | |
| 0006590 | |
| 0007275 | |
| 0007420 | |
| 0007507 | |
| 0009887 | |
| 0035050 | |
| 0035116 | |
| 0035162 | |
| 0045444 | |
| 0045944 |
| Alias | CRSP1 |
|---|---|
| CRSP210 | |
| DRIP205 | |
| DRIP230 | |
| Peroxisome proliferator-activated receptor binding protein | |
| PPAR binding protein | |
| PPARG binding protein | |
| RB18A | |
| Thyroid receptor interacting protein 2 | |
| TRAP220 | |
| TRIP2 | |
| vitamin D receptor-interacting protein 230 kD | |
| vitamin D receptor-interacting complex component DRIP205 | |
| PPARBP | |
| PPARGBP | |
| thyroid hormone receptor interactor II | |
| Thyroid receptor interacting protein II | |
| CRSP200 | |
| p53 regulatory protein RB18A | |
| CRSP I | |
| PPARGBPs | |
| mgc71488 | |
| Thyroid receptor interactive protein 2 | |
| Thyroid receptor interactive protein II | |
| vitamin D receptor-interactive protein 230 kD | |
| thyroid hormone receptor interactor 2 | |
| Thyroid hormone receptor-associated protein complex component TRAP220 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus |
| MedLine Reference | 10747854 |
|---|---|
| 10882104 | |
| 11724781 | |
| 12037571 | |
| 12093747 | |
| 12446761 | |
| 12466851 | |
| 14500757 | |
| 14638676 | |
| 15681609 | |
| 9325263 | |
| 9708794 | |
| 10198638 | |
| 10235266 | |
| 10235267 | |
| 12218053 |
| LocusLink ID | 103752 |
|---|---|
| 19014 | |
| 5469 | |
| 9327 |
| FunctionalClass | chromatin binding |
|---|---|
| protein binding | |
| DNA binding | |
| RNA polymerase II transcription mediator | |
| ligand-dependent nuclear receptor transcription coactivator | |
| receptor | |
| thyroid hormone receptor binding | |
| transcriptional activator | |
| vitamin D receptor binding | |
| transcription coactivator |
| GO Cellular Component | mediator complex |
|---|---|
| nucleus |
| Cell Localization | Plasma membrane |
|---|---|
| Nucleus |
| Pathway | PPAR all |
|---|---|
| PPARgamma | |
| FXR | |
| PPARalpha | |
| CAR | |
| ERbeta | |
| ERalpha | |
| GR | |
| NOR1 | |
| HNF4a | |
| TR | |
| NR common targets | |
| NR common regulators | |
| NR CYP ABCs |
| GO Biological Process | androgen receptor signaling pathway |
|---|---|
| regulation of transcription, DNA-dependent | |
| transcription | |
| transcription initiation from RNA polymerase II promoter | |
| DNA replication | |
| brain development | |
| development | |
| embryonic development (sensu Mammalia) | |
| embryonic heart tube development | |
| embryonic hemopoiesis | |
| embryonic hindlimb morphogenesis | |
| embryonic placenta development | |
| eye development (sensu Mammalia) | |
| fat cell differentiation | |
| heart development | |
| liver development | |
| organogenesis | |
| positive regulation of transcription from RNA polymerase II promoter | |
| thyroid hormone generation | |
| transcription from RNA polymerase II promoter |
| Group | Nuclear receptors |
|---|---|
| Nrs |
| Source | Curated |
|---|