Protein : NFATC1


Name	NFATC1
Description	The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components [BLAST Evalue to experimental molecule = 7.51e-97]
Owner	Public
URN	urn:agi-llid:4772
Connectivity	38
Notes	The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.
Hugo ID	7775


Chromosome position	18q23
	18 54.0 cM


Alias	NFATc
	NF-ATc
	transcription factor NF-ATc
	NFAT transcription complex cytosolic component
	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent I
	Nfatc Is
	Nfatc1s
	nuclear factor of activated T-cells, cytoplasmic 1
	2210017P03Rik
	nuclear factor of activated T-cells, cytoplasmic I
	Nuclear factor ATC I
	Nfatcb
	NFAT transcription complex cytosolic component
	Nfatc1
	NF-ATc1
	nuclear factor of activated T-cells, cytosolic component I
	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent
	nuclear factor of activated T-cells, cytosolic component 1
	Nfatc I
	NF-ATc I
	RIKEN cDNA 2210017P03 gene
	NFAT2
	Nuclear factor ATC1
	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1


Hugo Symbol	NFATC1


KEGG pathway	Calcium signaling pathway
	Wnt signaling pathway


GO Cellular Component	cytoplasm
	nucleus


Cell Localization	Nucleus


Pathway	Jnk-mapk
	SAPK-JNK Signaling
	KDR -> NFATC1 signalling pathway
	FLT1 -> NFATC1 signalling pathway
	IGF1-BST1
	IGF1-IGF2R
	IGF1-LRP5
	IL4-FCER2
	IL4-IL4R
	TNF-IL15RA
	TNF-NGFR
	TNF-TNFRSF1B
	TNFSF11-TNFRSF11A
	TNFSF11-TNFRSF11B
	VEGF-CD44
	VEGF-EGFR
	VEGF-FLT1
	VEGF-FLT4
	VEGF-GPC1
	VEGF-IL1R1
	PPAR all
	PPARgamma


GO Biological Process	transcription from Pol II promoter
	regulation of transcription, DNA-dependent
	transcription from RNA polymerase II promoter
	G1/S transition of mitotic cell cycle
	calcium ion transport
	epithelial to mesenchymal transition
	heart development
	transcription


Group	Transcription factors


State	nuclear factor of activated T-cells, cytosolic component 1 isoform B
	nuclear factor of activated T-cells, cytosolic component 1 isoform C
	nuclear factor of activated T-cells, cytosolic component 1 isoform D
	nuclear factor of activated T-cells, cytosolic component 1 isoform E
	nuclear factor of activated T-cells, cytosolic component 1 isoform A


State Description	Transcript Variant: This variant (4) differs in the 3' UTR and has multiple coding region differences compared to variant 1. It uses a downstream start codon and an alternate splice site in the 3' coding region, which results in a frameshift. The encod...
	Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region compared to variant 1, which results in a frameshift. The encoded isoform (B) has a longer and distinct C-terminus compared to isoform A.
	Transcript Variant: This variant (3) differs in the 5' and 3' UTRs, and the coding region compared to variant 1. The resulting isoform (C) has distinct N- and C- termini compared to isoform A.
	Transcript Variant: This variant (1) represents the shortest transcript and encodes isoform A.
	Transcript Variant: This variant (5) differs in the 5' and 3' UTRs, and the coding region compared to variant 1. The resulting isoform (E, also known as C.b) has distinct N- and C- termini compared to isoform A.


MGI ID	102469


Swiss-Prot Accession	O95644


OMIM ID	600489
	OMIM:600489


Source	BIND
	Curated