| Name | TCF4 |
|---|---|
| Description | transcription factor 4 |
| Owner | Public |
| URN | urn:agi-llid:6925 |
| Connectivity | 47 |
| Notes | TCF4 encodes transcription factor 4, a basic helix-turn-helix transcription factor. The protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. TCF4 is expressed predominantly in pre-B-cells, although it is found in other tissues as well. TCF4 is known to produce multiple transcripts; however as the complete structure is only known for the transcript that encodes the b isoform, that is the variant presented here. |
| Hugo ID | 11634 |
| Microarray ID | 1368841_at |
|---|---|
| rc_aa956941_at | |
| u09228_at | |
| A_42_P524370 | |
| 1416723_at | |
| 1416724_x_at | |
| 1424089_a_at | |
| 160483_at | |
| 99588_at | |
| u16322_s_at | |
| 112288_at | |
| 112289_g_at | |
| 1426572_at | |
| 1426573_at | |
| A_51_P265137 | |
| A_52_P424847 | |
| A_51_P490817 | |
| A_51_P490823 | |
| 213891_s_at | |
| 228837_at | |
| M74719_at | |
| 89997_at | |
| A_23_P27332 | |
| A_14_P104100 | |
| A_14_P132228 | |
| A_14_P136688 | |
| A_14_P120853 | |
| A_14_P125347 | |
| M74719 | |
| 222146_s_at | |
| 36605_at | |
| 56764_at | |
| 56694_at | |
| 68265_g_at | |
| 68263_at | |
| 203753_at | |
| 212382_at | |
| 212385_at | |
| 212386_at | |
| 212387_at | |
| M564 | |
| OH3168 | |
| OR1544 | |
| P048 |
| Chromosome position | 18q12.1 |
|---|---|
| 18q21.1 |
| GO ID | 0003690 |
|---|---|
| 0003700 | |
| 0045944 | |
| 0003677 | |
| 0003702 | |
| 0005634 | |
| 0006357 | |
| 0003714 | |
| 0005515 | |
| 0005667 | |
| 0006350 | |
| 0006355 | |
| 0007275 | |
| 0008013 | |
| 0030528 | |
| 0045449 |
| Alias | similar to MITF-2B protein |
|---|---|
| TFE | |
| ASP-I2 | |
| E2-2 | |
| SEF2-1A | |
| ITF-2bs | |
| ASP-I2s | |
| SEF2-1s | |
| SEF2 Is | |
| TCF-4Ns | |
| Immunoglobulin transcription factor 2 | |
| ITF-2 | |
| MITF-2A | |
| MITF-2B | |
| R8f DNA-binding protein | |
| SEF2-1 | |
| SEF2-1B | |
| TCF4 | |
| transcription factor 4 | |
| transcription factor 4 isoform b | |
| transcription factor ITF-2 | |
| Transcription factor-4 (immunoglobulin transcription factor-2) | |
| 5730422P05Rik | |
| RIKEN cDNA 5730422P05 gene | |
| transcription factor IV | |
| ITF2_HUMAN | |
| Immunoglobulin transcription factor II | |
| SL3-3 enhancer factor II | |
| E2 II | |
| ITF II | |
| transcription factor ITF II | |
| SEF2 I | |
| SEF II | |
| ITF-2b | |
| SEF-2 | |
| SL3-3 enhancer factor 2 | |
| TCF-4N | |
| T-cell factor 4 | |
| T-cell factor IV |
| Organism | Homo sapiens |
|---|---|
| Rattus norvegicus | |
| Mus musculus |
| MedLine Reference | 12874278 |
|---|---|
| 14762206 | |
| 15351717 | |
| 8999959 | |
| 7913462 | |
| 1681116 | |
| 2105528 |
| LocusLink ID | 21413 |
|---|---|
| 114843 | |
| 6925 | |
| 84382 | |
| 67762 |
| FunctionalClass | DNA binding |
|---|---|
| double-stranded DNA binding | |
| transcription factor | |
| RNA polymerase II transcription factor | |
| beta-catenin binding | |
| protein binding | |
| transcription corepressor | |
| transcription regulator |
| RGD ID | 69271 |
|---|
| Hugo Symbol | TCF4 |
|---|
| Unigene ID | Hs.200285 |
|---|---|
| Rn.23354 | |
| Mm.139815 |
| GO Cellular Component | nucleus |
|---|---|
| transcription factor complex |
| Cell Localization | Nucleus |
|---|
| Pathway | TGFBR1 -> TCF4 signalling pathway |
|---|---|
| C3-CR2 | |
| FGF2-FGFR3 | |
| FGF2-GPC1 | |
| FGF2-TGFBR3 | |
| PTH-IL6ST | |
| WNT1-LRP5 | |
| WNT1-LRP6 | |
| WNT1-ROR2 | |
| PPAR all | |
| PPARgamma | |
| AR | |
| ERalpha |
| GO Biological Process | regulation of transcription from RNA polymerase II promoter |
|---|---|
| positive regulation of transcription from RNA polymerase II promoter | |
| development | |
| regulation of transcription | |
| regulation of transcription, DNA-dependent | |
| transcription | |
| positive regulation of transcription from Pol II promoter | |
| regulation of transcription from Pol II promoter |
| Group | Transcription factors |
|---|
| MGI ID | 98506 |
|---|
| Swiss-Prot Accession | P15884 |
|---|
| OMIM ID | 602272 |
|---|
| Source | Curated |
|---|