Protein : CDKN1A


Name	CDKN1A
Description	cyclin-dependent kinase inhibitor 1A (P21)
Owner	Public
URN	urn:agi-llid:1026
Connectivity	203
Notes	This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported.
Hugo ID	1784


Alias	CDNA
	CDNA_HUMAN
	P-21
	P 21
	CDKI
	CDK-interaction protein 1
	CDKN1
	cyclin-dependent kinase inhibitor 1A (P21)
	cyclin-dependent kinase inhibitor 1A (p21, Cip1)
	DNA synthesis inhibitor
	MDA-6
	melanoma differentiation associated protein 6
	p21/Waf-1
	p21/Waf-1/Cip1
	p21WAF
	WAF1
	wild-type p53-activated fragment 1
	p21 Cip1/Waf1/Sic1
	Cyclin-dependent kinase inhibitor I
	wild-type p53-activated fragment I
	CDK-interaction protein I
	cyclin-dependent kinase inhibitor 1A
	CDK-interacting protein 1
	SDI1
	CDK-interacting protein I
	SDI I
	CDKN I
	p21/Cip1/Waf I
	WAF I
	MDA VI
	CAP20
	p21/Waf I
	Cip1/Waf1
	cyclin-dependent kinase inhibitor P21 Cip1/Waf1
	CipI/WafI
	Waf-1/Cip1
	p21/Cip1/Waf1/SDI1
	Cdkn1a
	p21/Cip
	cyclin-dependent kinase inhibitor P21
	CDN1_HUMAN
	melanoma differentiating associated protein 6
	melanoma differentiating associated protein VI
	CDK-interactive protein I
	CDK-interactive protein 1
	p21/Waf-1/Cip I
	melanoma differentiation associated protein VI
	p21/Cip I
	P(21)
	p21/Cip1/Waf1
	p21/Cip1
	1A
	Cip1
	P21
	mda6
	p21Cip1
	CDNA_MOUSE
	p21 WAF1/CIP1 tumor suppressor protein


FunctionalClass	cyclin-dependent protein kinase inhibitor
	metal ion binding
	protein kinase
	cyclin binding
	kinase
	protein binding
	protein kinase inhibitor


RGD ID	69328


Hugo Symbol	CDKN1A


GO Cellular Component	cyclin-dependent protein kinase holoenzyme complex
	nucleus


Cell Localization	Cytoplasm
	Nucleus


Pathway	ATM signaling
	p53 Signaling
	NOTCH1 -> MYOD1 signalling pathway
	AGER -> MYOG signalling pathway
	AGER -> HMG1 signalling pathway
	IL6ST -> MYOG signalling pathway
	PECAM1 -> RBL2 signalling pathway
	BMP2-ACVR1
	BMP2-ACVR2
	BMP2-BMPR1A
	BMP2-BMPR1B
	BMP2-BMPR2
	BMP4-ACVR1
	BMP4-BMPR1A
	BMP4-BMPR1B
	BMP4-BMPR2
	BMP7-ACVR1
	BMP7-ACVR2
	BMP7-ACVR2B
	BMP7-BMPR1A
	BMP7-BMPR1B
	BMP7-BMPR2
	CSF2-CSF2RA
	EGF-EGFR
	EGF-ERBB2
	EGF-ERBB3
	EGF-ERBB4
	EGF-LRP8
	EGF-NGFR
	F2-ITGAV
	F2-LRP1
	F2-LRP2
	F2-THBD
	FGF2-CD44
	FGF2-FGFR1
	FGF2-FGFR2
	FGF2-FGFR3
	FGF2-GPC1
	FGF2-TGFBR3
	GDF8-ACVR2
	HGF-CD44
	HGF-FGFR2
	HGF-IL6R
	HGF-MET
	IFNA1-CR2
	IFNA1-IFNAR1
	IFNA1-IFNAR2
	IFNG-HLA-C
	IFNG-IFNGR1
	IFNG-IFNGR2
	IGF1-BST1
	IGF1-IGF1R
	IGF1-IGF2R
	IGF1-LRP5
	IL10-IL10RA
	IL10-TNFRSF7
	IL1B-HLA-DRB1
	IL1B-IL1R1
	IL1B-IL1RAP
	IL1B-IL6R
	IL2-IL15RA
	IL2-IL2RA
	IL2-IL2RB
	IL2-IL2RG
	IL2-IL4R
	IL3-CD8A
	IL3-CSF2RB2
	IL3-EPOR
	IL3-IL3RA
	IL4-FCER2
	IL4-IL2RG
	IL4-IL4R
	IL6-IL6R
	IL6-IL6ST
	IL6-LIFR
	IL6-TNFRSF5
	INHBA-ACVR1B
	INHBA-ACVR2
	INHBA-ACVR2B
	INHBA-ACVRL1
	INS-EGFR
	INS-HLA-DRB1
	INS-IGF1R
	INS-TFRC
	KITLG-KIT
	NGFB-NGFR
	NGFB-NTRK1
	NGFB-NTRK2
	NGFB-NTRK3
	NRG1-CD44
	NRG1-EGFR
	NRG1-ERBB2
	NRG1-ERBB3
	NRG1-ERBB4
	OSM-CD22
	OSM-IL6ST
	OSM-LIFR
	PF4-THBD
	TGFA-EGFR
	TGFB1-ACVR1
	TGFB1-ACVR1B
	TGFB1-ACVR2
	TGFB1-ACVR2B
	TGFB1-ACVRL1
	TGFB1-BMPR1B
	TGFB1-CD44
	TGFB1-IGF2R
	TGFB1-IL6R
	TGFB1-M6PR
	TGFB1-SELE
	TGFB1-SELL
	TGFB1-TGFBR1
	TGFB1-TGFBR2
	TGFB1-TGFBR3
	TNF-IL15RA
	TNF-NGFR
	TNF-TNFRSF1A
	TNF-TNFRSF1B
	TNF-TNFRSF6
	TNFSF6-TNFRSF6
	PPAR all
	PPARgamma
	AR
	ERalpha
	NR common targets


GO Biological Process	negative regulation of cyclin dependent protein kinase activity
	positive regulation of B-cell proliferation
	regulation of cell cycle
	regulation of cyclin dependent protein kinase activity
	cell cycle
	negative regulation of apoptosis
	negative regulation of cyclin dependent protein kinase
	positive regulation of B cell proliferation
	positive regulation of non-apoptotic programmed cell death
	regulation of progression through cell cycle
	response to DNA damage stimulus
	response to UV
	cell cycle arrest
	induction of apoptosis by intracellular signals
	negative regulation of cell proliferation
	regulation of cyclin dependent protein kinase


Group	Kinases


State Description	Transcript Variant: This variant (1) lacks an internal sequence segment in the 5' UTR. Variants 1 and 2 encode the same protein.
	Transcript Variant: This variant (2) contains an extra internal sequence segment in the 5' UTR region. Variants 1 and 2 encode the same protein.


MGI ID	104556


Swiss-Prot Accession	P38936


OMIM ID	116899
	OMIM:116899


Source	Curated