| Name | STAT3 |
|---|---|
| Description | signal transducer and activator of transcription 3 (acute-phase response factor) |
| Owner | Public |
| URN | urn:agi-llid:6774 |
| Connectivity | 319 |
| Notes | The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Two alternatively spliced transcript variants encoding distinct isoforms have been described. |
| Hugo ID | 11364 |
| Microarray ID | NM_012747 |
|---|---|
| 1370224_at | |
| rc_ai008865_s_at | |
| rc_ai059916_f_at | |
| rc_ai236828_s_at | |
| x91810_at | |
| A_43_P11545 | |
| 1426587_a_at | |
| u06922_s_at | |
| A_51_P201480 | |
| L29277 | |
| 208991_at | |
| 208992_s_at | |
| 243213_at | |
| 289_at | |
| 39708_at | |
| L29277_at | |
| A_32_P203619 | |
| A_14_P138552 | |
| A_14_P134953 | |
| A_14_P119759 | |
| A_14_P117722 | |
| A_14_P117979 | |
| A_24_P116805 | |
| A_23_P107206 | |
| A_23_P107201 | |
| A_23_P100790 | |
| A_23_P100795 | |
| A_24_P923962 | |
| A_14_P120263 | |
| M285 | |
| R592 | |
| OR0759A | |
| 134 | |
| OH7530 | |
| O0030 | |
| 99099_at | |
| Msa.287.0_at | |
| 1460700_at | |
| 1424272_at | |
| BC019168 | |
| 228113_at | |
| I_960040 |
| Chromosome position | 17q21.31 |
|---|---|
| 10q32.1 | |
| 11 60.5 cM |
| GO ID | GO:0045182 |
|---|---|
| GO:0005515 | |
| GO:0003677 | |
| GO:0004871 | |
| GO:0003700 | |
| GO:0016563 | |
| GO:0007259 | |
| GO:0006953 | |
| GO:0006355 | |
| GO:0007242 | |
| GO:0007165 | |
| GO:0006357 | |
| GO:0006366 | |
| GO:0005737 | |
| GO:0005634 | |
| GO:0005062 | |
| GO:0007399 | |
| GO:0006928 | |
| GO:0000122 | |
| 0000122 | |
| 0003700 | |
| 0004871 | |
| 0005062 | |
| 0005509 | |
| 0005634 | |
| 0005737 | |
| 0006928 | |
| 0006953 | |
| 0007242 | |
| 0007259 | |
| 0007399 | |
| 0008134 | |
| 0019221 | |
| 0001754 | |
| 0003677 | |
| 0005515 | |
| 0005886 | |
| 0006350 | |
| 0006355 | |
| 0006357 | |
| 0006366 | |
| 0007165 | |
| 0016563 | |
| 0046983 |
| Alias | 6030446J10Rik |
|---|---|
| 1190028D05Rik | |
| 1190028D05 | |
| hypothetical protein 1190028D05 | |
| RIKEN cDNA 1190028D05 gene | |
| acute phase response factor | |
| STA3_MOUSE | |
| STAT3 protein | |
| signal transducer and activator of transcription 3 (acute-phase response factor) | |
| RIKEN cDNA 6030446J10 gene | |
| 1110034C02Rik | |
| Acute-phase response factor | |
| APRF | |
| DNA-binding protein APRF | |
| Signal transducer and activator of transcription 3 | |
| signal transducer and activator of transcription 3 (acute-phase response fa | |
| signal transducer and activator of transcription 3 isoform 1 | |
| signal transducer and activator of transcription 3 isoform 2 | |
| Stat3 | |
| FLJ20882 | |
| hypothetical protein MGC16063 | |
| MGC16063 | |
| signal transducer and activator of transcription 3 isoform I | |
| signal transducer and activator of transcription 3 isoform II | |
| Signal transducer and activator of transcription III |
| Organism | Homo sapiens |
|---|---|
| Rattus norvegicus | |
| Mus musculus | |
| Human |
| MedLine Reference | 10205054 |
|---|---|
| 15664994 | |
| 7512451 | |
| 8675499 | |
| 9670957 | |
| 8530402 | |
| 11579100 | |
| 12426389 | |
| 12634107 | |
| 12738762 | |
| 12746441 | |
| 12826573 | |
| 15207851 | |
| 15749075 |
| LocusLink ID | 330767 |
|---|---|
| 320848 | |
| 104593 | |
| 20848 | |
| 25125 | |
| 6774 | |
| 114129 | |
| 68733 |
| FunctionalClass | calcium ion binding |
|---|---|
| hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer | |
| signal transducer | |
| transcription factor | |
| transcription factor binding | |
| protein binding | |
| DNA binding | |
| protein dimerization | |
| transcriptional activator |
| RGD ID | 3772 |
|---|
| Hugo Symbol | STAT3 |
|---|
| Unigene ID | Rn.10247 |
|---|---|
| Mm.249934 | |
| Hs.463059 | |
| Mm.246790 | |
| Hs.421342 | |
| Mm.196029 | |
| Hs.321677 | |
| Mm.4269 |
| Keyword | nucleus |
|---|---|
| transcription factor | |
| JAK | |
| actin | |
| DNA binding activity | |
| DNA | |
| nuclei |
| GO Cellular Component | cytoplasm |
|---|---|
| nucleus | |
| plasma membrane |
| GO Molecular Function | protein binding |
|---|---|
| DNA binding | |
| signal transducer activity | |
| transcription factor activity | |
| transcriptional activator activity | |
| hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity | |
| protein binding activity | |
| DNA binding activity | |
| translation regulator activity |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm |
| Pathway | p40 MAPK |
|---|---|
| PDGF signaling | |
| IL-6 signaling | |
| EGF signaling | |
| MAPK-ERK in Growth and Differentiation | |
| Jak-Stat Pathway from IL6 Receptor | |
| Inhibition of Apoptosis | |
| oncostatin M | |
| M-CSF | |
| LIF | |
| Leptin | |
| KITLG | |
| IL9 | |
| IL7 | |
| IL6 | |
| IL5 | |
| IL3 | |
| IL29 | |
| IL28B | |
| IL27 | |
| IL26 | |
| IL24 | |
| IL23 | |
| IL22 | |
| IL21 | |
| IL20 | |
| IL2 | |
| IL19 | |
| IL18 | |
| IL17A | |
| IL15 | |
| IL12 | |
| IL11 | |
| IL10 | |
| IL1 | |
| IFN alpha | |
| HGF | |
| Growth Hormone | |
| G-CSF | |
| EGF | |
| CNTF | |
| Cardiotrophin-1 like | |
| Cardiotrophin-1 | |
| NCAM1 -> STAT3 signalling pathway | |
| NOTCH1 -> STAT3 signalling pathway | |
| OPRD1 -> STAT3 signalling pathway | |
| OPRM1 -> STAT3 signalling pathway | |
| TEK -> STAT3 signalling pathway | |
| TNFRSF1A -> STAT3 signalling pathway | |
| ADRA1B -> STAT3 signalling pathway | |
| ADRB1 -> STAT3 signalling pathway | |
| ADRB2 -> STAT3 signalling pathway | |
| AGTR1 -> STAT3 signalling pathway | |
| ALK -> STAT3 signalling pathway | |
| IFNAR1 -> STAT3 signalling pathway | |
| IFNAR2 -> STAT3 signalling pathway | |
| IFNGR1 -> STAT3 signalling pathway | |
| IGF1R -> STAT3 signalling pathway | |
| IL1R1 -> STAT3 signalling pathway | |
| IL2RB -> STAT3 signalling pathway | |
| IL2RG -> STAT3 signalling pathway | |
| IL3RA -> STAT3 signalling pathway | |
| IL5RA -> STAT3 signalling pathway | |
| IL6R -> STAT3 signalling pathway | |
| IL6ST -> STAT3 signalling pathway | |
| IL9R -> STAT3 signalling pathway | |
| IL10RA -> STAT3 signalling pathway | |
| IL10RB -> STAT3 signalling pathway | |
| IL11RA -> STAT3 signalling pathway | |
| IL13RA1 -> STAT3 signalling pathway | |
| ITGB2 -> STAT3 signalling pathway | |
| BDKRB2 -> STAT3 signalling pathway | |
| CXCR4 -> STAT3 signalling pathway | |
| KIT -> STAT3 signalling pathway | |
| CCKBR -> STAT3 signalling pathway | |
| LEPR -> STAT3 signalling pathway | |
| LIFR -> STAT3 signalling pathway | |
| TNFRSF5 -> STAT3 signalling pathway | |
| EPHA3 -> STAT3 signalling pathway | |
| EPHA4 -> STAT3 signalling pathway | |
| EPOR -> STAT3 signalling pathway | |
| ERBB2 -> STAT3 signalling pathway | |
| CRL3 -> STAT3 signalling pathway | |
| FGFR1 -> STAT3 signalling pathway | |
| FGFR3 -> STAT3 signalling pathway | |
| GHR -> STAT3 signalling pathway | |
| OSMR -> STAT3 signalling pathway | |
| PDGFRA -> STAT3 signalling pathway | |
| PDGFRB -> STAT3 signalling pathway | |
| CCR1 -> STAT3 signalling pathway | |
| CCR2 -> STAT3 signalling pathway | |
| CCR5 -> STAT3 signalling pathway | |
| IL21R -> STAT3 signalling pathway | |
| CSF1R -> STAT3 signalling pathway | |
| CSF3R -> STAT3 signalling pathway | |
| IL22R -> STAT3 signalling pathway | |
| PRLR -> STAT3 signalling pathway | |
| PTAFR -> STAT3 signalling pathway | |
| PTPRC -> STAT3 signalling pathway | |
| RET -> STAT3 signalling pathway | |
| EGFR -> STAT3 signalling pathway | |
| MET -> STAT3 signalling pathway | |
| MPL -> STAT3 signalling pathway | |
| AGT-LRP2 | |
| AREG-EGFR | |
| BMP2-ACVR1 | |
| BMP2-ACVR2 | |
| BMP2-BMPR1A | |
| BMP2-BMPR1B | |
| BMP2-BMPR2 | |
| BMP4-ACVR1 | |
| BMP4-BMPR1A | |
| BMP4-BMPR1B | |
| BMP4-BMPR2 | |
| BTC-EGFR | |
| CCL19-IL2RB | |
| CCL2-CD4 | |
| CLC-CNTFR | |
| CLC-IL6ST | |
| CNTF-CNTFR | |
| CNTF-IL6ST | |
| CNTF-LIFR | |
| CSF1-CSF1R | |
| CSF1-IL6R | |
| CSF1-TNFRSF5 | |
| CSF2-CSF2RA | |
| CSF3-CSF3R | |
| CSF3-IL6R | |
| CTF1-IL6ST | |
| DTR-CD44 | |
| DTR-EGFR | |
| DTR-ERBB4 | |
| EFNA2-EPHA3 | |
| EGF-EGFR | |
| EGF-ERBB2 | |
| EGF-ERBB3 | |
| EGF-ERBB4 | |
| EGF-LRP8 | |
| EGF-NGFR | |
| EPO-EPOR | |
| EREG-EGFR | |
| F2-ITGAV | |
| F2-LRP1 | |
| F2-LRP2 | |
| F2-THBD | |
| FGF1-FGFR1 | |
| FGF1-FGFR2 | |
| FGF1-FGFR3 | |
| FGF1-GPC1 | |
| FGF2-CD44 | |
| FGF2-FGFR1 | |
| FGF2-FGFR2 | |
| FGF2-FGFR3 | |
| FGF2-GPC1 | |
| FGF2-TGFBR3 | |
| GH1-GHR | |
| GH1-IGF1R | |
| GH1-PRLR | |
| GRO1-EGFR | |
| HGF-CD44 | |
| HGF-FGFR2 | |
| HGF-IL6R | |
| HGF-MET | |
| IFNA1-CR2 | |
| IFNA1-IFNAR1 | |
| IFNA1-IFNAR2 | |
| IFNB1-IFNAR1 | |
| IFNB1-IFNAR2 | |
| IFNG-HLA-C | |
| IFNG-IFNGR1 | |
| IFNG-IFNGR2 | |
| IGF1-BST1 | |
| IGF1-IGF2R | |
| IGF1-LRP5 | |
| IL10-IL10RA | |
| IL10-TNFRSF7 | |
| IL11-IL6R | |
| IL11-IL6ST | |
| IL13-IL13RA1 | |
| IL13-IL13RA2 | |
| IL13-IL2RG | |
| IL13-IL4R | |
| IL15-IL15RA | |
| IL15-IL2RB | |
| IL15-IL2RG | |
| IL17-IL17R | |
| IL17D-WSX1 | |
| IL1B-HLA-DRB1 | |
| IL1B-IL1R1 | |
| IL1B-IL1RAP | |
| IL1B-IL6R | |
| IL2-IL15RA | |
| IL2-IL2RA | |
| IL2-IL2RB | |
| IL2-IL2RG | |
| IL2-IL4R | |
| IL21-IL2RG | |
| IL3-CD8A | |
| IL3-CSF2RB2 | |
| IL3-EPOR | |
| IL3-IL3RA | |
| IL4-FCER2 | |
| IL4-IL2RG | |
| IL4-IL4R | |
| IL5-IL5RA | |
| IL5-IL6ST | |
| IL6-IL6R | |
| IL6-IL6ST | |
| IL6-LIFR | |
| IL6-TNFRSF5 | |
| IL7-IL2RG | |
| IL7-IL7R | |
| IL9-IL9R | |
| INHBA-ACVR1B | |
| INHBA-ACVR2 | |
| INHBA-ACVR2B | |
| INHBA-ACVRL1 | |
| INS-EGFR | |
| INS-HLA-DRB1 | |
| INS-TFRC | |
| KITLG-KIT | |
| LEP-LEPR | |
| LEP-LRP2 | |
| LIF-IGF2R | |
| LIF-IL6ST | |
| LIF-LIFR | |
| NGFB-NGFR | |
| NGFB-NTRK1 | |
| NGFB-NTRK2 | |
| NGFB-NTRK3 | |
| NRG1-CD44 | |
| NRG1-EGFR | |
| NRG1-ERBB2 | |
| NRG1-ERBB3 | |
| NRG1-ERBB4 | |
| NTF3-CNTFR | |
| OSM-CD22 | |
| OSM-IL6ST | |
| OSM-LIFR | |
| PDGFB-PDGFRB | |
| PGF-FLT1 | |
| PGF-KDR | |
| PRL-PRLR | |
| PTH-IL6ST | |
| SDF1-IL6ST | |
| SELPLG-ICAM1 | |
| TGFA-EGFR | |
| TGFB1-ACVR1 | |
| TGFB1-ACVR1B | |
| TGFB1-ACVR2 | |
| TGFB1-ACVR2B | |
| TGFB1-ACVRL1 | |
| TGFB1-BMPR1B | |
| TGFB1-CD44 | |
| TGFB1-IGF2R | |
| TGFB1-IL6R | |
| TGFB1-M6PR | |
| TGFB1-SELE | |
| TGFB1-SELL | |
| TGFB1-TGFBR1 | |
| TGFB1-TGFBR2 | |
| TGFB1-TGFBR3 | |
| THPO-EPOR | |
| THPO-MPL | |
| TNF-IL15RA | |
| TNF-NGFR | |
| TNF-TNFRSF1B | |
| TNFSF10-TNFRSF10A | |
| TNFSF10-TNFRSF10B | |
| TNFSF10-TNFRSF1A | |
| TNFSF10-TNFRSF6 | |
| VEGF-CD44 | |
| VEGF-EGFR | |
| VEGF-FLT1 | |
| VEGF-FLT4 | |
| VEGF-GPC1 | |
| VEGF-IL1R1 | |
| VEGF-KDR | |
| DuPont 4 | |
| Ben Common regulators | |
| PPAR all | |
| PPARgamma | |
| PPARalpha | |
| AR | |
| ERalpha | |
| GR | |
| NR common regulators |
| GO Biological Process | JAK-STAT cascade |
|---|---|
| acute-phase response | |
| cell motility | |
| cytokine and chemokine mediated signaling pathway | |
| intracellular signaling cascade | |
| negative regulation of transcription from RNA polymerase II promoter | |
| neurogenesis | |
| eye photoreceptor cell differentiation | |
| regulation of transcription from RNA polymerase II promoter | |
| regulation of transcription, DNA-dependent | |
| signal transduction | |
| transcription | |
| transcription from RNA polymerase II promoter | |
| transcription from Pol II promoter | |
| negative regulation of transcription from Pol II promoter | |
| regulation of transcription from Pol II promoter |
| Group | Sh2 |
|---|---|
| Transcription factors |
| State | isoform 3 |
|---|---|
| isoform 1 | |
| isoform 2 | |
| signal transducer and activator of transcription 3 isoform 2 | |
| signal transducer and activator of transcription 3 isoform 1 | |
| signal transducer and activator of transcription 3 isoform 3 | |
| p |
| State Description | Transcript Variant: This variant (3), also called Stat3B or Stat3beta, lacks a segment in the 3' coding region, resulting in an early termination codon, compared to variant 1. Variant 3 encodes isoform 3, which has a shorter and distinct C-terminus, co... |
|---|---|
| Transcript Variant: This variant (1) encodes the longest isoform (1) of this protein. | |
| Transcript Variant: This variant (1) represents a longer transcript, and encodes a longer isoform (1). | |
| Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. Variant 2 encodes isoform 2, which lacks a single amino acid, compared to isoform 1. | |
| Transcript Variant: This variant (2) lacks a segment in the 5' UTR and 3 nt within the CDS, as compared to variant 1. The resulting isoform (2) lacks an amino acid compared to isoform 1. | |
| Transcript Variant: This variant (3), also called STAT3B or STAT3beta, lacks a segment in the coding region resulting in an early termination codon, compared to variant 1. Variant 3 encodes isoform 3, which has a shorter and distinct C-terminus compare... |
| MGI ID | 103038 |
|---|---|
| 3036227 | |
| 2444860 |
| Swiss-Prot Accession | P40763 |
|---|
| OMIM ID | 102582 |
|---|---|
| OMIM:102582 |
| Source | Curated |
|---|---|
| BIND | |
| ResNet |