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CDDO-Im downregulates RARA expression in acute promyelocytic leukemic cells. Cryptic translocation of PML/RARA on 17q. A rare event in acute promyelocytic leukemia. IL-3-induced enhancement of retinoic acid receptor activity is mediated through Stat5, which physically associates with recombinant human retinoic acid receptors in an IL-3-dependent manner. In a 9-cis retinoic acid-dependent fashion in cells in vitro, retinoic acid receptor alpha isoform stimulates the expression of reporter constructs containing the site that binds aldehyde dehydrogenase-2. In normal epithelium, both RAR-alpha and -gamma present with minimal nuclear accumulation. Increased in luminal epithelial nuclei in prostatic intra-epithelial neoplasia. Increase in expression of RARalpha is associated with esophageal squamous cell carcinomas. Interactions of STAT5b-RARalpha, a novel acute promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways. PML-retinoic acid receptor alpha activities are regulated by neutrophil elastase in early myeloid cells. RAR pan-agonists and the RARalpha-selective agonist Am580, but not RXR agonists, stimulate the expression of SOX9 in a wide variety of retinoid-inhibited breast cancer cell lines. RARA has a distinct role and functional mode in mediating tretinoin-induced signalling. REVIEW the biology of RARalpha, and the RARalpha fusion proteins created in APL and the normal forms of the partner proteins. Results show an increased DNA binding of the retinoic acid receptor alpha/retinoid X receptor alpha heterodimer and the stability of nuclear localization of this heterodimer, which facilitates signal transduction. Results show that both RARalpha and RARbeta are mediators in the anticancer function of All-trans retinoic acid via AP-1 activity inhibition. Retinoid-induced G1 arrest and differentiation activation are associated with a switch to cyclin-dependent kinase-activating kinase hypophosphorylation of the receptor. Transient transfection of either all-trans-retinoic acid (ATRA) receptor alpha or estrogen receptor alpha expression vectors increased cellular retinoic acid binding protein II expression in MDA-MB-231 cells. UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia. Analysis of estrogen activation of the retinoic acid receptor alpha1 gene in breast cancer cells. Data suggest that Sp110b is a transcriptional cofactor negatively regulating retinoic acid receptor alpha-mediated transcription. Depletion of vitamin A and retinoid receptors by UV irradiation, together with unchanged or even increased c-Jun levels, might seriously interfere with retinoid signaling and thus promote future tumor development, especially in keratinocytes. Endocrine molecule retinoic acid, and its receptor RARs play a critical role in alveolarization during the neonatal period of the lung. Induces acute promyelocytic leukemia in a mouse model. Inhibition of monocyte differentiation all contribute to the oncogenic activity of PML-RARalpha. Intrinsic ageing of human skin is accompanied by significant elevation in the content of RAR alpha. Mutational analysis of human retinoic acid receptor alpha ligand binding domain. Nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form. Nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR short form. Obesity is associated with an inverse relationship between peroxisome proliferator-activated receptor gamma and RARalpha expressions in subcutaneous adipose tissue. Retinoic acid receptor-alpha is synthesized by activated polymorphonuclear leukocytes. Role in development of myelodi leukemia with promyelocytic features. The silencing of the RAR alpha2 promoter by hypermethylation may play a contributory role in the dysregulation of RA signaling in mammary tumorigenesis. Two critical hits for promyelocytic leukemia.
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