| Name | CCND1 |
|---|---|
| Description | cyclin D1 |
| Owner | Public |
| URN | urn:agi-llid:595 |
| Connectivity | 228 |
| Notes | The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. |
| Hugo ID | 1582 |
| Microarray ID | 1371150_at |
|---|---|
| rc_aa957218_at | |
| rc_ai231257_at | |
| x75207_s_at | |
| 132780_at | |
| 1417419_at | |
| 1417420_at | |
| 1448698_at | |
| 167827_at | |
| 94231_at | |
| 94232_at | |
| msa.25060.0_f_at | |
| msa.575.0_f_at | |
| w08016_s_at | |
| A_51_P262759 | |
| A_51_P262766 | |
| X59798 | |
| M64349 | |
| 38418_at | |
| 208712_at | |
| 214019_at | |
| 208711_s_at | |
| 2017_s_at | |
| 2020_at | |
| X59798_at | |
| A_23_P202837 | |
| A_14_P124581 | |
| A_14_P102675 | |
| A_14_P117958 | |
| A_24_P124550 | |
| A_24_P193011 | |
| M139 | |
| R050 | |
| OR0218A | |
| 647 | |
| OH7838 |
| Chromosome position | 1q42 |
|---|---|
| 11q13 | |
| 7 72.3 cM | |
| 5q36 |
| GO ID | 0000074 |
|---|---|
| 0000082 | |
| 0005634 | |
| 0008372 | |
| 0051301 | |
| 0000910 | |
| 0000307 | |
| 0000320 | |
| 0004672 | |
| 0005515 | |
| 0005829 | |
| 0006468 | |
| 0007049 | |
| 0016301 | |
| 0016538 | |
| 0045444 |
| Alias | mgc94339 |
|---|---|
| BCL I | |
| D1 cyclin | |
| D11S287E | |
| G1/S-specific cyclin D1 | |
| parathyroid adenomatosis 1 | |
| PRAD1 oncogene | |
| U21B31 | |
| B-cell CLL/lymphoma 1 | |
| BCL1 | |
| BCL-1 oncogene | |
| Ccnd1 | |
| CGD1 | |
| cyclin D1 | |
| CGD1_HUMAN | |
| cyclin D | |
| PRAD1: parathyroid adenomatosis 1 | |
| PRAD1: parathyroid adenomatosis I | |
| B-cell CLL/lymphoma I | |
| parathyroid adenomatosis I | |
| PRAD1 | |
| Ccnd I | |
| CGD I | |
| PRAD I | |
| HGNC:988 | |
| cyclin D1 (PRAD1: parathyroid adenomatosis 1) | |
| Cyl-1 | |
| bcl-1 | |
| CGD1_MOUSE |
| Organism | Rattus norvegicus |
|---|---|
| Mus musculus | |
| Homo sapiens | |
| Human |
| MedLine Reference | 7980531 |
|---|---|
| 8033213 | |
| 11809706 | |
| 12124778 | |
| 12502791 | |
| 12588994 | |
| 12970760 |
| LocusLink ID | 893 |
|---|---|
| 313771 | |
| 58919 | |
| 12443 | |
| 595 | |
| 101546 |
| FunctionalClass | cyclin-dependent protein kinase regulator |
|---|---|
| protein binding | |
| kinase | |
| protein kinase |
| RGD ID | 68384 |
|---|
| Hugo Symbol | CCND1 |
|---|
| Unigene ID | Mm.273049 |
|---|---|
| Rn.22279 | |
| Hs.371468 | |
| Hs.523852 |
| KEGG pathway | Cell cycle |
|---|---|
| Focal adhesion | |
| Jak-STAT signaling pathway | |
| Wnt signaling pathway |
| GO Cellular Component | cyclin-dependent protein kinase holoenzyme complex |
|---|---|
| cytosol | |
| cellular component unknown | |
| nucleus |
| Cell Localization | Nucleus |
|---|
| Pathway | p53 Signaling |
|---|---|
| AGT-LRP2 | |
| AREG-EGFR | |
| BDNF-NCAM1 | |
| BDNF-NTRK3 | |
| BTC-EGFR | |
| CSF1-CSF1R | |
| CSF1-IL6R | |
| CSF1-TNFRSF5 | |
| DTR-CD44 | |
| DTR-EGFR | |
| DTR-ERBB4 | |
| EGF-EGFR | |
| EGF-ERBB2 | |
| EGF-ERBB3 | |
| EGF-ERBB4 | |
| EGF-LRP8 | |
| EGF-NGFR | |
| F2-ITGAV | |
| F2-LRP1 | |
| F2-LRP2 | |
| F2-THBD | |
| FGF1-FGFR1 | |
| FGF1-FGFR2 | |
| FGF1-FGFR3 | |
| FGF1-GPC1 | |
| FGF2-CD44 | |
| FGF2-FGFR1 | |
| FGF2-FGFR2 | |
| FGF2-FGFR3 | |
| FGF2-GPC1 | |
| FGF2-TGFBR3 | |
| FGF7-FGFR2 | |
| FGF7-GPC1 | |
| GRO1-EGFR | |
| HGF-CD44 | |
| HGF-FGFR2 | |
| HGF-IL6R | |
| HGF-MET | |
| IFNG-HLA-C | |
| IFNG-IFNGR1 | |
| IFNG-IFNGR2 | |
| IGF1-BST1 | |
| IGF1-IGF1R | |
| IGF1-IGF2R | |
| IGF1-LRP5 | |
| IGF2-IGF2R | |
| IL2-IL15RA | |
| IL2-IL2RA | |
| IL2-IL2RB | |
| IL2-IL2RG | |
| IL2-IL4R | |
| IL3-CD8A | |
| IL3-CSF2RB2 | |
| IL3-EPOR | |
| IL3-IL3RA | |
| IL4-FCER2 | |
| IL4-IL2RG | |
| IL4-IL4R | |
| IL5-IL5RA | |
| IL5-IL6ST | |
| IL6-IL6R | |
| IL6-IL6ST | |
| IL6-LIFR | |
| IL6-TNFRSF5 | |
| IL7-IL2RG | |
| IL7-IL7R | |
| INS-EGFR | |
| INS-HLA-DRB1 | |
| INS-IGF1R | |
| INS-TFRC | |
| LEP-LEPR | |
| LEP-LRP2 | |
| LIF-IGF2R | |
| LIF-IL6ST | |
| LIF-LIFR | |
| MUC4-ERBB2 | |
| NGFB-NGFR | |
| NGFB-NTRK1 | |
| NGFB-NTRK2 | |
| NGFB-NTRK3 | |
| NRG1-ERBB2 | |
| OSM-CD22 | |
| OSM-IL6ST | |
| OSM-LIFR | |
| PRL-PRLR | |
| PTH-IL6ST | |
| SDF1-CD4 | |
| SDF1-IL6ST | |
| TGFA-EGFR | |
| TGFB1-ACVR1 | |
| TGFB1-ACVR1B | |
| TGFB1-ACVR2 | |
| TGFB1-ACVR2B | |
| TGFB1-ACVRL1 | |
| TGFB1-BMPR1B | |
| TGFB1-CD44 | |
| TGFB1-IGF2R | |
| TGFB1-IL6R | |
| TGFB1-M6PR | |
| TGFB1-SELE | |
| TGFB1-SELL | |
| TGFB1-TGFBR1 | |
| TGFB1-TGFBR2 | |
| TGFB1-TGFBR3 | |
| THPO-EPOR | |
| THPO-MPL | |
| TNF-IL15RA | |
| TNF-NGFR | |
| TNF-TNFRSF1A | |
| TNF-TNFRSF1B | |
| TNF-TNFRSF6 | |
| TNFSF11-TNFRSF11A | |
| TNFSF11-TNFRSF11B | |
| VEGF-CD44 | |
| VEGF-EGFR | |
| VEGF-FLT1 | |
| VEGF-FLT4 | |
| VEGF-GPC1 | |
| VEGF-IL1R1 | |
| VEGF-KDR | |
| WNT1-LRP5 | |
| WNT1-LRP6 | |
| WNT1-ROR2 | |
| DuPont 4 | |
| PPAR all | |
| PPARgamma | |
| PPARalpha | |
| AR | |
| ERalpha | |
| TR | |
| NR common targets | |
| NR common regulators |
| GO Biological Process | cytokinesis |
|---|---|
| cell cycle | |
| fat cell differentiation | |
| protein amino acid phosphorylation | |
| re-entry into mitotic cell cycle | |
| G1/S transition of mitotic cell cycle | |
| cell division | |
| regulation of progression through cell cycle | |
| cell growth and/or maintenance | |
| adipocyte differentiation | |
| regulation of cell cycle |
| MGI ID | 88313 |
|---|
| Swiss-Prot Accession | P24385 |
|---|
| OMIM ID | 168461 |
|---|---|
| 254500 | |
| 193300 | |
| OMIM:168461 | |
| OMIM:254500 | |
| OMIM:193300 |
| Source | Curated |
|---|