Protein : SMAD3


Name	SMAD3
Description	SMAD, mothers against DPP homolog 3 (Drosophila)
Owner	Public
URN	urn:agi-llid:4088
Connectivity	227
Notes	SUMMARY: transcription factor; important component of the TGF-beta signaling pathway [RGD]
Hugo ID	6769


Chromosome position	8q24
	15q22.33


Alias	MAD homolog 3 (Drosophila)
	MAD (mothers against decapentaplegic Drosophila) homolog 3
	Smad 3
	JV-15-2
	SMAD, mothers against DPP homolog 3 (Drosophila)
	MGC60396
	JV15-2s
	JV15-Ls
	hSMAD3s
	hSMAD3
	Madh3
	Mothers against DPP homolog III
	HsT17436
	JV15-L
	SMAD, mothers against DPP homolog 3
	SMAD, mothers against DPP homolog III
	JV15 II
	Mothers against DPP homolog 3
	MAD (mothers against decapentaplegic homolog III
	Mothers against decapentaplegic, drosophila, homolog of, 3
	SMAD3
	homolog of Drosophila Mothers against decapentaplegic 3
	JV15-2
	MAD (mothers against decapentaplegic homolog 3
	MAD (mothers against decapentaplegic, Drosophila) homolog 3
	MAD homolog 3
	MAD, mothers against decapentaplegic homolog 3 (Drosophila)
	Mothers against decapentaplegic homolog 3 (SMAD 3)
	HSPC193
	AU022421
	expressed sequence AU022421
	DKFZP586N0721
	homolog of Drosophila Mothers against decapentaplegic III
	MAD (mothers against decapentaplegic, Drosophila) homolog III
	MAD homolog III
	Mothers against decapentaplegic, drosophila, homolog of, III


FunctionalClass	double-stranded DNA binding
	protein binding
	transcription factor binding
	transcriptional activator
	transcription factor


RGD ID	3032


Hugo Symbol	SMAD3


GO Molecular Function	transcription factor activity
	transcription factor binding
	protein binding
	transcription factor binding activity
	protein binding activity
	tumor suppressor


Cell Localization	Nucleus
	Cytoplasm


Pathway	TGF-beta signaling
	TGFR2-TGFR1
	AcvR2B-ALK7
	AcvR2B-AcvR1B
	AcvR2B-AcvR1
	AcvR2-AcvR1
	ACVR1B -> MADH3 signalling pathway
	ACVR2 -> MADH3 signalling pathway
	ACVRL1 -> MADH3 signalling pathway
	NOTCH1 -> MADH3 signalling pathway
	NTRK1 -> MADH3 signalling pathway
	TGFBR1 -> MADH3 signalling pathway
	CD4 -> MADH3 signalling pathway
	BMP2-ACVR1
	BMP4-ACVR1
	BMP7-ACVR1
	BMP7-ACVR2
	BMP7-ACVR2B
	BMP7-BMPR1A
	BMP7-BMPR1B
	BMP7-BMPR2
	EGF-ERBB2
	EGF-ERBB3
	EGF-ERBB4
	EGF-LRP8
	EGF-NGFR
	GDF11-ACVR1B
	GDF8-ACVR2
	HGF-CD44
	HGF-FGFR2
	HGF-IL6R
	HGF-MET
	IFNG-HLA-C
	IFNG-IFNGR1
	IFNG-IFNGR2
	IGF1-BST1
	IGF1-IGF2R
	IGF1-LRP5
	IL1B-HLA-DRB1
	IL1B-IL1R1
	IL1B-IL1RAP
	IL1B-IL6R
	INHBA-ACVR1B
	INHBA-ACVR2
	INHBA-ACVR2B
	INHBA-ACVRL1
	NGFB-NGFR
	NGFB-NTRK1
	NGFB-NTRK2
	NGFB-NTRK3
	NMU-TGFBR1
	PTH-IL6ST
	TGFB1-ACVR1
	TGFB1-ACVR1B
	TGFB1-ACVR2
	TGFB1-ACVR2B
	TGFB1-ACVRL1
	TGFB1-BMPR1B
	TGFB1-CD44
	TGFB1-IGF2R
	TGFB1-IL6R
	TGFB1-M6PR
	TGFB1-SELE
	TGFB1-SELL
	TGFB1-TGFBR1
	TGFB1-TGFBR2
	TGFB1-TGFBR3
	TNF-IL15RA
	TNF-NGFR
	TNF-TNFRSF1B
	DuPont 4
	Ben Common regulators
	PPAR all
	PPARgamma
	AR
	ERalpha
	GR
	HNF4a
	NR common regulators


GO Biological Process	SMAD protein heteromerization
	common-partner SMAD protein phosphorylation
	mesoderm formation
	negative regulation of transcription from RNA polymerase II promoter
	organogenesis
	paraxial mesoderm morphogenesis
	positive regulation of transcription
	positive regulation of transcription from RNA polymerase II promoter
	positive regulation of transcription, DNA-dependent
	regulation of binding
	regulation of epithelial cell proliferation
	regulation of myogenesis
	regulation of transforming growth factor beta receptor signaling pathway
	regulation of transcription, DNA-dependent
	transcription
	transcription from RNA polymerase II promoter
	transforming growth factor beta receptor signaling pathway
	negative regulation of transcription from Pol II promoter
	positive regulation of transcription from Pol II promoter
	transcription from Pol II promoter
	TGFbeta receptor signaling pathway
	regulation of TGFbeta receptor signaling pathway


Group	Transcription factors


State	p


MGI ID	1201674


Swiss-Prot Accession	Q92940


OMIM ID	603109
	OMIM:603109