| Name | NFKB1 |
|---|---|
| Description | Nuclear factor kappa-B, subunit 1; p50 subunit of NF-kappaB; nuclear factor-kappaB p50. |
| Owner | Public |
| URN | urn:agi-llid:4790 |
| Connectivity | 73 |
| Notes | This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. |
| Hugo ID | 7794 |
| Microarray ID | A_51_P283759 |
|---|---|
| 38438_at | |
| 209239_at | |
| 1377_at | |
| 1378_g_at | |
| M58603_at | |
| rc_aa098834_s_at | |
| A_23_P30024 | |
| A_14_P115699 | |
| A_14_P124513 | |
| A_14_P122511 | |
| M272 | |
| 36 | |
| OH7553 | |
| R224 | |
| OR0383 | |
| O0053 | |
| A_43_P15232 | |
| 1427705_a_at | |
| 98427_s_at | |
| l28117_s_at |
| Chromosome position | 4q24 |
|---|---|
| 2q43 | |
| 3 68.9 cM |
| GO ID | 0003690 |
|---|---|
| 0006979 | |
| 0007515 | |
| 0016563 | |
| 0045944 | |
| 0046983 | |
| 0003677 | |
| 0006350 | |
| 0016566 | |
| 0003700 | |
| 0005515 | |
| 0005634 | |
| 0005737 | |
| 0006355 | |
| 0006366 | |
| 0006915 | |
| 0006916 | |
| 0006954 | |
| 0007165 | |
| 0009618 | |
| 0019733 | |
| 0045083 | |
| 0045892 | |
| 0048535 |
| Alias | EBP-1 |
|---|---|
| NF-KB1 | |
| nuclear factor kappa-B, subunit 1 | |
| nuclear factor kappa-B, subunit | |
| subunit of NF-kappaB | |
| NF-kappaB p50 | |
| Nuclear factor NF-kappa-B p105 subunit | |
| Nfkb1 | |
| Nuclear factor of kappa light chain gene enhancer in B-cells 1 (p105) | |
| nuclear factor kappa-B, subunit I | |
| Nfkb I | |
| DNA-binding factor KBF I | |
| KBF I | |
| NF-kappaB I | |
| NF-KB I | |
| EBP I | |
| NF-KB1s | |
| NF-KB Is | |
| nuclear factor kappa b p105 subunit | |
| nuclear factor nf-kappa-b p50 subunit | |
| nuclear factor kappa-b dna binding subunit | |
| dkfzp686c01211 | |
| nuclear factor-kappaB p50 | |
| p50 subunit of NF-kappaB | |
| p50/p105 | |
| KBF1 | |
| NF-kappaB1 | |
| MGC54151 | |
| NFKB-p105 | |
| NFKB-p50 | |
| DNA-binding factor KBF1 | |
| P(50) | |
| NF-kB | |
| NF-kappaB | |
| p50 | |
| nuclear factor of kappa light chain gene enhancer in B-cells 1, p105 | |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | |
| DNA binding factor KBF1 | |
| KBF1_HUMAN | |
| NF-kappa-B | |
| P 50 | |
| P-50 |
| Organism | Human |
|---|---|
| Homo sapiens | |
| Mus musculus | |
| Rattus norvegicus |
| MedLine Reference | 12193536 |
|---|---|
| 14576180 | |
| 10426996 | |
| 10811897 | |
| 10928981 | |
| 14624448 | |
| 1992489 | |
| 10687308 | |
| 11976687 | |
| 12198705 | |
| 12618484 | |
| 12970181 | |
| 14568984 | |
| 15845452 |
| LocusLink ID | 81736 |
|---|---|
| 18033 | |
| 4790 |
| FunctionalClass | DNA binding |
|---|---|
| specific transcriptional repressor | |
| transcriptional activator | |
| protein binding | |
| transcription factor | |
| double-stranded DNA binding | |
| protein dimerization |
| RGD ID | 70498 |
|---|
| Hugo Symbol | NFKB1 |
|---|
| Unigene ID | Rn.2411 |
|---|---|
| Mm.256765 | |
| Hs.431926 | |
| Hs.160557 |
| KEGG pathway | Apoptosis |
|---|---|
| Calcium signaling pathway | |
| MAPK signaling pathway | |
| Toll-like receptor signaling pathway |
| GO Cellular Component | cytoplasm |
|---|---|
| nucleus |
| Cell Localization | Nucleus |
|---|
| Pathway | NF kappa B |
|---|---|
| TLR2 -> NFKB1 signalling pathway | |
| TLR4 -> NFKB1 signalling pathway | |
| ICAM1 -> NFKB1 signalling pathway | |
| ERBB3 -> NFKB1 signalling pathway | |
| EGF-ERBB3 | |
| IFNA1-CR2 | |
| IFNA1-IFNAR1 | |
| IFNA1-IFNAR2 | |
| IFNG-HLA-C | |
| IFNG-IFNGR1 | |
| IFNG-IFNGR2 | |
| IL1B-HLA-DRB1 | |
| IL1B-IL1R1 | |
| IL1B-IL1RAP | |
| IL1B-IL6R | |
| INS-EGFR | |
| INS-HLA-DRB1 | |
| INS-TFRC | |
| NRG1-CD44 | |
| NRG1-ERBB2 | |
| NRG1-ERBB3 | |
| NRG1-ERBB4 | |
| NRG2-ERBB3 | |
| TNF-IL15RA | |
| TNF-NGFR | |
| TNF-TNFRSF1B | |
| PPAR all | |
| PPARgamma | |
| AR |
| GO Biological Process | transcription from Pol II promoter |
|---|---|
| anti-apoptosis | |
| antibacterial humoral response (sensu Vertebrata) | |
| apoptosis | |
| inflammatory response | |
| regulation of transcription, DNA-dependent | |
| response to pathogenic bacteria | |
| signal transduction | |
| transcription from RNA polymerase II promoter | |
| lymph node development | |
| negative regulation of interleukin-12 biosynthesis | |
| negative regulation of transcription, DNA-dependent | |
| transcription | |
| lymph gland development | |
| positive regulation of transcription from RNA polymerase II promoter | |
| response to oxidative stress |
| Group | Transcription factors |
|---|
| MGI ID | 97312 |
|---|
| Swiss-Prot Accession | P19838 |
|---|
| OMIM ID | 164011 |
|---|---|
| OMIM:164011 |
| Source | BIND |
|---|---|
| Curated |