| Name | MPG |
|---|---|
| Description | N-methylpurine-DNA glycosylase |
| Owner | Public |
| URN | urn:agi-llid:4350 |
| Connectivity | 7 |
| Notes | 3' end of the Mid1 gene, localized 68 kb upstream the humanzeta globin gene on 16p. AAG is a mammalian enzyme that can act on all three purine deamination bases, hypoxanthine, xanthine, and oxanine. Effects of hydrogen bonding within a damaged base pair on the activity of wild type and DNA-intercalating mutants of the human alkyladenine DNA glycosylase. MPG mRNA expression was slightly higher in astrocytic tumors than in adjacent tissue, suggesting a role in astrocytic tumors & the possibility that the altered MPG expression & intracellular localization could be associated with astrocytic tumorigenesis. Methylated DNA-binding domain 1 cooperates with this enzyme for transcriptional repression and DNA repair. Alkyladenine DNA-glycosylase activates neutral lesions by protonation of the nucleobase leaving group. Analysis of substrate specificity of human 3-methyladenine-DNA glycosylase. Plays a role in maintaining integrity of the genome by recruiting DNA repair proteins to actively transcribing DNA [3-methyladenine DNA glycosylase]. |
| Microarray ID | 1368410_at |
|---|---|
| x56420_at | |
| A_42_P740209 | |
| A_51_P366161 | |
| 37768_at | |
| 203686_at | |
| 229122_x_at | |
| M74905_s_at | |
| Z69720_at | |
| A_23_P163659 | |
| A_14_P124014 | |
| A_24_P48162 | |
| OR3036 | |
| S41 | |
| OH1983A | |
| A061 | |
| T16 |
| Chromosome position | 16p13.3 |
|---|---|
| 10q12 | |
| 11 16.0 cM |
| GO ID | 0003684 |
|---|---|
| 0003905 | |
| 0005654 | |
| 0006284 | |
| 0006307 | |
| 0016787 | |
| 0003677 | |
| 0005634 | |
| 0006281 | |
| 0006974 |
| Alias | 3-alkyladenine DNA glycosylase |
|---|---|
| 3-methyladenine DNA glycosylase | |
| 9830006D05 | |
| ADPG | |
| alkyladenine DNA glycosylase | |
| ANPG | |
| APNG | |
| N-methylpurine-DNA glycocylase | |
| N-methylpurine-DNA glycosylase | |
| 3-methyladenine DNA glycosylase I | |
| DNA 3-methyladenine glycosylase I | |
| DNA 3-methyladenine glycosylase I activity | |
| DNA-3-methyladenine glycosylase | |
| DNA-3-methyladenine glycosidase I | |
| n-methylpurine-dna glycosylase, mpg | |
| pig16 | |
| proliferation-inducing protein XI | |
| proliferation-inducing protein 11 | |
| proliferation-inducing protein 16 | |
| cra36.1 (3-methyl-adenine dna glycosylase) | |
| cra36.1 | |
| N-methylpurine- DNA glycosirase | |
| deoxyribonucleate 3-methyladenine glycosidase I | |
| alkylpurine-DNA-N-glycosylase | |
| 3-methyladenine DNA glycosidase | |
| Aag protein | |
| Aag gene |
| Organism | Mus musculus |
|---|---|
| Homo sapiens | |
| Rattus norvegicus |
| MedLine Reference | 15177041 |
|---|---|
| 9371767 | |
| 10854423 | |
| 1645538 |
| LocusLink ID | 4350 |
|---|---|
| 24561 | |
| 268395 | |
| 17477 | |
| 103693 |
| FunctionalClass | alkylbase DNA N-glycosylase |
|---|---|
| damaged DNA binding | |
| hydrolase | |
| DNA binding |
| GO Cellular Component | nucleus |
|---|---|
| nucleoplasm |
| Pathway | PPAR all |
|---|---|
| PPARgamma | |
| RXR | |
| ERalpha | |
| TR |
| GO Biological Process | DNA repair |
|---|---|
| response to DNA damage stimulus | |
| DNA dealkylation | |
| base-excision repair |
| EC Number | 3.2.2.21 |
|---|
| Source | Curated |
|---|