| Name | RXRB |
|---|---|
| Description | retinoid X receptor, beta |
| Owner | Public |
| URN | urn:agi-llid:6257 |
| Connectivity | 12 |
| Notes | This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). This receptor forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. The gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. An alternatively spliced transcript variant has been described, but its full length sequence has not been determined. Diminished RXRbeta expression might be related to prostate cancer progression. Because responsiveness to retinoic acid treatments depends on expression of different receptors, it is important to study their expression before therapy. Family studies revealed significant linkage disequilibrium between the RXRB alleles and a number of HLA-DPB1 alleles. The retinoid X receptor, beta is expressed widely and can be found in almost every tissue. The role of retinoid X receptor messenger RNA expression in curatively resected non-small cell lung cancer. Partial dissociation of TR/retinoid X receptor heterodimer complex from the TRE is involved in the suppression of transcription induced by polychlorinated biphenyls. Polymorphism is unrelated to schizophrenia or alcoholism. |
| Microarray ID | A_51_P314830 |
|---|---|
| A_52_P519689 | |
| M84820 | |
| 215098_at | |
| 215099_s_at | |
| 209148_at | |
| 1362_s_at | |
| 37763_at | |
| M84820_s_at | |
| X63522_s_at | |
| X65463_at | |
| A_32_P463219 | |
| A_23_P59179 | |
| A_14_P112536 | |
| M119 | |
| R357 | |
| OR0537A | |
| 487 | |
| OH9463 | |
| MA480 |
| Chromosome position | 6p21.3 |
|---|---|
| 17 18.49 cM | |
| 20p12 |
| GO ID | 0003700 |
|---|---|
| 0003707 | |
| 0003713 | |
| 0004886 | |
| 0005496 | |
| 0005634 | |
| 0006350 | |
| 0006355 | |
| 0046872 | |
| 0003677 | |
| 0004872 | |
| 0004879 | |
| 0005515 | |
| 0030375 | |
| 0042809 | |
| 0042974 | |
| 0046966 | |
| 0046982 |
| Alias | RXR-beta |
|---|---|
| MGC1831 | |
| MHC class I promoter binding protein | |
| nuclear receptor co-regulator I | |
| nuclear receptor co-regulator 1 | |
| DAUDI6s | |
| Extensin precursor (Cell wall hydroxyproline-rich glycoprotein) | |
| expressed sequence AL023085 | |
| AL023085 | |
| DAUDI6 | |
| H-2RIIBP | |
| RCoR-1 | |
| Retinoic acid receptor RXR-beta | |
| retinoid X receptor, beta | |
| NR2B2 | |
| RCoR I | |
| RXRB |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MedLine Reference | 1662118 |
|---|---|
| 12466851 | |
| 15207008 |
| LocusLink ID | 361801 |
|---|---|
| 25006 | |
| 6257 | |
| 20182 | |
| 106680 |
| FunctionalClass | DNA binding |
|---|---|
| ligand-dependent nuclear receptor | |
| metal ion binding | |
| retinoid-X receptor | |
| steroid binding | |
| steroid hormone receptor | |
| transcription coactivator | |
| transcription factor | |
| protein binding | |
| receptor | |
| protein heterodimerization | |
| retinoic acid receptor binding | |
| thyroid hormone receptor binding | |
| thyroid hormone receptor coactivator | |
| vitamin D receptor binding |
| GO Cellular Component | nucleus |
|---|
| Cell Localization | Plasma membrane |
|---|---|
| Nucleus |
| Pathway | PPAR all |
|---|---|
| PPARgamma | |
| PPARalpha | |
| LXR | |
| RXR | |
| TR | |
| NR common targets | |
| NR common regulators | |
| NR CYP ABCs |
| GO Biological Process | regulation of transcription, DNA-dependent |
|---|---|
| transcription |
| Group | Nuclear receptors |
|---|---|
| Ph | |
| Nrs |
| Source | Curated |
|---|