Protein : MIZ1

Name MIZ1
Description protein inhibitor of activated STAT, 2
Owner Public
URN urn:agi-llid:9063
Connectivity 29
Notes PIASx may function as a co-repressor of Stat4. Required for upregulation of a large group of genes in response to DNA damage, a function that is regulated by c-Myc, but not by 14-3-3eta and represses the expression of many genes.

Microarray ID 1387299_at
af044058_at
rc_ai137350_at
A_42_P762629
100941_at
100942_at
109340_at
109814_r_at
1419454_x_at
1426456_a_at
160912_i_at
163207_at
aa386903_at
aa386903_g_at
A_51_P339857
A_51_P339858
A_52_P534203
A_52_P85945
AF077953
37433_at
214593_at
214442_s_at
37432_g_at
37431_at
55199_g_at
55194_at
74866_at
1555513_at
1555514_a_at
235107_at
238700_at
243624_at
rc_aa412087_at
rc_aa609704_at
A_23_P130316
A_14_P138317
A_24_P382266
OR1585
OH4249
V040

GenBank ID BAC30652
BAC37407
BAC39710
BAE43280
BC005596
BC034711
NC_000084
NM_008602
NP_032628
NT_039675
Q8C5D8
AAK48938
AF077953
AF077954
AF361054
BC015190
NC_000018
NM_004671
NM_173206
NP_004662
NP_775298
NT_010966
NT_086888
O75928
AAC36704
AAC36705
AAD13349
AAH78775
AF044058
BC078775
NC_005117
NM_053337
NP_445789
NW_047516
Q6AZ28
AAH15190
AAB96678
AAF12825
AAH05596
AAH34711
AF039567
AF201391
AK014871
AK015627
AK015663
AK015850
AK018146
AK029716
AK032463
AK040627
AK078097
AK078813
AK086653
AK086922
AK149142
BAB29594
BAC26579

Chromosome position 18q21.1
18q12.3
18 E3

GO ID 0007275
0008270
0030521
0045893
0046872
0003702
0006351
0006355
0050681
0003677
0003713
0005634
0006350
0006512

Alias Miz1
AI462206
Msx-interacting-zinc finger
PIASX-BETA
SIZ2
inhibitor of activated STAT X
inhibitor of activated STAT 10
4930520E11Rik
6330408K17Rik
piasx-alpha
pias2
miz
Msx-interactive-zinc finger
AU018068
ARIP3
GNB:4176737
PIASxalpha6
PIASxb
RIKEN cDNA 4930520E11 gene

Organism Mus musculus
Homo sapiens
Rattus norvegicus

MedLine Reference 12466851
15572661
9256341

LocusLink ID 106913
17344
9063
106977
83422
67643
70728

FunctionalClass RNA polymerase II transcription factor
DNA binding
androgen receptor binding
metal ion binding
transcription coactivator
zinc ion binding

KEGG pathway Jak-STAT signaling pathway

GO Cellular Component nucleus

Cell Localization Nucleus

Pathway PPAR all
PPARgamma
AR
NR common regulators

GO Biological Process regulation of transcription, DNA-dependent
transcription, DNA-dependent
androgen receptor signaling pathway
development
positive regulation of transcription, DNA-dependent
transcription
ubiquitin cycle

Group Transcription factors

Source Curated