| Name | FABP4 |
|---|---|
| Description | fatty acid binding protein 4, adipocyte |
| Owner | Public |
| URN | urn:agi-llid:2167 |
| Connectivity | 12 |
| Notes | FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. Loss of expression of A-FABP is associated with progression of bladder carcinoma. A pre-lipolysis complex containing at least AFABP and HSL exists. Fatty acid binding protein 4 and PPARgamma work together to influence a biologic pathway affecting insulin sensitivity and body composition. Intra-pair correlations revealed that FATP4 expression was signifcantly up-regulated in acquired obesity. Observations suggest that oxLDL-mediated increase in gene expression accelerate cholesterol ester accumulation, and that this is an important component of the genetic program regulating conversion of macrophages to foam cells. |
| Microarray ID | 1368271_a_at |
|---|---|
| rc_ai169612_at | |
| 100567_at | |
| 1417023_a_at | |
| 1451263_a_at | |
| k02109_f_at | |
| msa.376.0_f_at | |
| msa.4454.0_f_at | |
| A_51_P336830 | |
| A_51_P336833 | |
| 235978_at | |
| 38430_at | |
| 76163_at | |
| 203980_at | |
| j02874_at | |
| A_14_P136425 | |
| A_23_P8820 | |
| H162 | |
| OH0895A | |
| R707 | |
| OR0864 | |
| MA536 |
| Chromosome position | 8q21 |
|---|---|
| 2q23 | |
| 3 13.9 cM |
| GO ID | 0005504 |
|---|---|
| 0005625 | |
| 0005737 | |
| 0006810 | |
| 0005515 | |
| 0005215 | |
| 0005488 | |
| 0008289 |
| Alias | ALBP |
|---|---|
| fatty acid binding protein 4, adipocyte | |
| Fatty acid-binding protein, adipocyte | |
| lipid binding protein-like | |
| adipocyte fatty acid binding protein | |
| Adipocyte lipid-binding protein | |
| adipocyte protein aP2 | |
| AFABP | |
| A-FABP | |
| fatty acid binding protein IV | |
| Fabp4 | |
| Lbpl | |
| ALBP/Ap2 | |
| fatty acid binding protein 4 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MedLine Reference | 2481498 |
|---|---|
| 10318917 |
| LocusLink ID | 84378 |
|---|---|
| 16804 | |
| 11770 | |
| 2167 | |
| 360339 | |
| 79451 |
| FunctionalClass | protein binding |
|---|---|
| fatty acid binding | |
| binding | |
| lipid binding | |
| transporter |
| GO Cellular Component | cytoplasm |
|---|---|
| soluble fraction |
| Cell Localization | Cytoplasm |
|---|
| Pathway | Full DuPont |
|---|---|
| DuPont 2 | |
| DuPont 3 | |
| DuPont 4 | |
| PPAR all | |
| PPARgamma | |
| PPARalpha | |
| PPARbeta |
| GO Biological Process | transport |
|---|
| Group | Full DuPont |
|---|
| Source | Curated |
|---|