| Name | PCK2 |
|---|---|
| Description | phosphoenolpyruvate carboxykinase 2 (mitochondrial) |
| Owner | Public |
| URN | urn:agi-llid:5106 |
| Connectivity | 41 |
| Notes | This gene encodes a member of the phosphoenolpyruvate carboxykinase (GTP) family. The protein is a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of GTP. A cytosolic form encoded by a different gene has also been characterized and is the key enzyme of gluconeogenesis in the liver. The encoded protein may serve a similar function, although it is constitutively expressed and not modulated by hormones such as glucagon and insulin that regulate the cytosolic form. Alternatively spliced transcript variants have been described. Results suggest that pepck2 gene expression is regulated by its 5' flanking region up to 822 bp, and 317 bp upstream of transcriptional start point. |
| Hugo ID | 8725 |
| Microarray ID | 128860_at |
|---|---|
| 1425615_a_at | |
| 1452620_at | |
| 97398_at | |
| aa044561_s_at | |
| msa.15442.0_s_at | |
| msa.27764.0_s_at | |
| msa.31074.0_s_at | |
| A_51_P110888 | |
| 37188_at | |
| 86118_at | |
| 202847_at | |
| X92720_at | |
| 73397_at | |
| A_23_P140207 | |
| A_14_P115524 | |
| A_23_P128817 | |
| OH2666 | |
| ST053 |
| Chromosome position | 14q11.2 |
|---|---|
| 14 21.0 cM |
| GO ID | 0000166 |
|---|---|
| 0004613 | |
| 0005525 | |
| 0005739 | |
| 0006094 | |
| 0016829 | |
| 0030145 | |
| 0004611 | |
| 0016831 |
| Alias | 9130022B02Rik |
|---|---|
| mitochondrial phosphoenolpyruvate carboxykinase 2 | |
| mitochondrial Phosphoenolpyruvate carboxykinase precursor (GTP) | |
| PCK2 | |
| PEPCK | |
| PEPCK2 | |
| PEPCK-M | |
| Phosphoenolpyruvate carboxykinase, mitochondrial precursor (GTP) | |
| Phosphoenolpyruvate carboxylase 2 | |
| RIKEN cDNA 9130022B02 gene | |
| Phosphoenolpyruvate carboxylase II | |
| phosphoenolpyruvate carboxykinase 2 (mitochondrial) | |
| PEPCK-Ms | |
| PEPCK2s | |
| gAF1/PCK2 | |
| 1810010O14Rik | |
| RIKEN cDNA 1810010O14 gene | |
| mitochondrial phosphoenolpyruvate carboxykinase II |
| Organism | Mus musculus |
|---|---|
| Homo sapiens |
| MedLine Reference | 14651853 |
|---|---|
| 8645161 |
| LocusLink ID | 69057 |
|---|---|
| 110830 | |
| 5106 | |
| 74551 | |
| 56186 |
| FunctionalClass | GTP binding |
|---|---|
| lyase | |
| manganese ion binding | |
| nucleotide binding | |
| phosphoenolpyruvate carboxykinase (GTP) | |
| carboxy-lyase | |
| phosphoenolpyruvate carboxykinase |
| Hugo Symbol | PCK2 |
|---|
| Unigene ID | Hs.75812 |
|---|---|
| Mm.29856 |
| KEGG pathway | Citrate cycle (TCA cycle) |
|---|---|
| Pyruvate metabolism |
| GO Cellular Component | mitochondrion |
|---|
| Cell Localization | Mitochondria |
|---|
| Pathway | EGF-ERBB3 |
|---|---|
| EGF-ERBB4 | |
| EGF-LRP8 | |
| EGF-NGFR | |
| INS-HLA-DRB1 | |
| INS-TFRC | |
| LEP-LRP2 | |
| TGFB1-ACVR1B | |
| TGFB1-ACVR2 | |
| TGFB1-ACVR2B | |
| TGFB1-ACVRL1 | |
| TGFB1-BMPR1B | |
| TGFB1-IGF2R | |
| TGFB1-SELE | |
| TGFB1-TGFBR1 | |
| TGFB1-TGFBR2 | |
| TGFB1-TGFBR3 | |
| Full DuPont | |
| DuPont 2 | |
| DuPont 4 | |
| PPAR all | |
| PPARgamma | |
| PGC1alpha | |
| RXR | |
| GR | |
| COUP-TF | |
| HNF4a | |
| NR common targets |
| GO Biological Process | gluconeogenesis |
|---|
| Group | Gtp binding proteins |
|---|---|
| Full DuPont |
| EC Number | 4.1.1.32 |
|---|
| MGI ID | 1860456 |
|---|
| Swiss-Prot Accession | Q16822 |
|---|
| OMIM ID | 261650 |
|---|
| Source | Curated |
|---|