Protein : MAPK7


Name	MAPK7
Description	mitogen-activated protein kinase 7
Owner	Public
URN	urn:agi-llid:5598
Connectivity	44
Notes	The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported.
Hugo ID	6880


Alias	BMK1 kinase
	Extracellular signal- regulated kinase 5
	mitogen-activated protein kinase 7
	PRKM7
	protein kinase mitogen-activated 7
	Extracellular signal- regulated kinase V
	mitogen-activated protein kinase VII
	big MAP kinase I
	MAPK7
	BMK I
	protein kinase mitogen-activated VII
	big MAP kinase 1
	ERK5
	BMK1


FunctionalClass	ATP binding
	MAP kinase
	nucleotide binding
	protein serine/threonine kinase
	transferase
	kinase
	protein kinase
	protein-tyrosine kinase


RGD ID	621505


Hugo Symbol	MAPK7


KEGG pathway	MAPK signaling pathway


GO Cellular Component	nucleus
	membrane


Pathway	p38 MAPK
	p40 MAPK
	TNF-alpha
	LT-alpha
	NOTCH1 -> MEF2C signalling pathway
	AGT-LRP2
	BDNF-NCAM1
	BDNF-NGFR
	BDNF-NTRK1
	BDNF-NTRK2
	BDNF-NTRK3
	CSF3-CSF3R
	CSF3-IL6R
	EGF-ERBB2
	EGF-ERBB3
	EGF-ERBB4
	EGF-LRP8
	EGF-NGFR
	F2-ITGAV
	F2-LRP1
	F2-LRP2
	F2-THBD
	FGF2-CD44
	FGF2-FGFR2
	FGF2-FGFR3
	FGF2-GPC1
	FGF2-TGFBR3
	GDNF-RET
	HGF-CD44
	HGF-FGFR2
	HGF-IL6R
	HGF-MET
	IGF1-BST1
	IGF1-IGF2R
	IGF1-LRP5
	LIF-IGF2R
	LIF-IL6ST
	LIF-LIFR
	NGFB-NGFR
	NGFB-NTRK2
	NGFB-NTRK3
	NTF3-CNTFR
	NTF3-NTRK2
	NTF3-NTRK3
	NTF5-NGFR
	NTF5-NTRK2
	NTF5-NTRK3
	TNF-IL15RA
	TNF-NGFR
	TNF-TNFRSF1B
	PPAR all
	PPARgamma


GO Biological Process	cell cycle
	protein amino acid phosphorylation
	signal transduction
	regulation of angiogenesis


Group	Kinases


EC Number	2.7.1.-
	2.7.1.37


State	isoform 1
	isoform 2


State Description	Transcript Variant: This variant (2) lacks a segment in the 5' region, which includes the translation start codon, when compared to variant 1. The translation of this transcript begins at a downstream in-frame start codon, and thus results in an N-term...
	Transcript Variant: This variant (3) is also known as BMK1 gamma. It contains a different 5' UTR, and encodes the identical isoform (1), as compared to variant 1.
	Transcript Variant: This variant (1) is also known as BMK1 alpha. It encodes a longer isoform (1), as compared to variant 2.
	Transcript Variant: This variant (4) is also known as BMK1 beta. It contains a different 5' UTR, and encodes the identical isoform (1), as compared to variant 1.


MGI ID	1346347


Swiss-Prot Accession	Q13164


OMIM ID	602521


Source	Curated