| Name | FGR |
|---|---|
| Description | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog |
| Owner | Public |
| URN | urn:agi-llid:2268 |
| Connectivity | 9 |
| Notes | Substitution of two relevant serines with glutamic acid residues in urokinase prevents urokinase activation of p55fgr needed for cell migration and adhesion. |
| Microarray ID | A_14_P136466 |
|---|---|
| M210 | |
| 713 | |
| OH1155 | |
| R717 | |
| OR0873 | |
| 1368693_at | |
| x57018_at | |
| A_43_P12403 | |
| 1419526_at | |
| 94697_at | |
| x16440_s_at | |
| A_51_P160780 | |
| M19722 | |
| 208438_s_at | |
| 1780_at | |
| M19722_at | |
| A_23_P103932 | |
| A_14_P116018 | |
| A_24_P51517 | |
| A_24_P316634 |
| Chromosome position | 4 64.6 cM |
|---|---|
| 5q36 | |
| 1p36.2-p36.1 |
| GO ID | 0000074 |
|---|---|
| 0004672 | |
| 0004674 | |
| 0005622 | |
| 0016301 | |
| 0050875 | |
| 0000166 | |
| 0004713 | |
| 0005524 | |
| 0006468 | |
| 0007242 | |
| 0009615 | |
| 0016740 |
| Alias | Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog |
|---|---|
| c-FGR | |
| Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog | |
| Oncogene FGR | |
| p55c-fgr | |
| protein-tyrosine kinase fgr | |
| Proto-oncogene tyrosine-protein kinase FGR | |
| Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene | |
| FGR_HUMAN | |
| P55-FGR |
| Organism | Mus musculus |
|---|---|
| Homo sapiens | |
| Rattus norvegicus |
| MedLine Reference | 12466851 |
|---|---|
| 2995972 | |
| 3003578 | |
| 15282299 |
| LocusLink ID | 14191 |
|---|---|
| 2268 | |
| 79113 |
| FunctionalClass | protein kinase |
|---|---|
| protein serine/threonine kinase | |
| ATP binding | |
| nucleotide binding | |
| protein-tyrosine kinase | |
| transferase | |
| kinase |
| GO Cellular Component | intracellular |
|---|
| Cell Localization | Cytoplasm |
|---|
| Pathway | PPAR all |
|---|---|
| PPARgamma | |
| ERalpha |
| GO Biological Process | cellular physiological process |
|---|---|
| regulation of progression through cell cycle | |
| intracellular signaling cascade | |
| protein amino acid phosphorylation | |
| response to virus |
| Group | Kinases |
|---|---|
| Sh2 |
| EC Number | 2.7.1.112 |
|---|
| Source | Curated |
|---|