| Name | CAV1 |
|---|---|
| Description | caveolin 1, caveolae protein, 22kDa |
| Owner | Public |
| URN | urn:agi-llid:857 |
| Connectivity | 235 |
| Notes | The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene. |
| Hugo ID | 1527 |
| Microarray ID | A_14_P120690 |
|---|---|
| A_24_P12626 | |
| H155 | |
| C373 | |
| OH1342B | |
| MB160 | |
| 229595_at | |
| I_930189 | |
| 1372111_at | |
| rc_AI012208_at | |
| 97849_at | |
| 160280_at | |
| 97850_at | |
| 1449145_a_at | |
| Msa.1833.0_f_at | |
| Msa.1833.0_at | |
| NM_007616.1 | |
| NM_007616 | |
| A_65_P01875 | |
| H3089D06-3 | |
| 1370131_at | |
| z46614cds_at | |
| A_65_P07350 | |
| A_51_P107302 | |
| 212097_at | |
| 36119_at | |
| 203065_s_at | |
| Z18951_at | |
| A_23_P134454 | |
| A_14_P139699 | |
| A_14_P122301 |
| Chromosome position | 4q21 |
|---|---|
| 7q31.1 | |
| 6 A2 |
| GO ID | GO:0005515 |
|---|---|
| GO:0006897 | |
| GO:0005901 | |
| GO:0016021 | |
| GO:0045121 | |
| GO:0005198 | |
| GO:0005887 | |
| GO:0008181 | |
| GO:0005624 | |
| 0000188 | |
| 0000299 | |
| 0001937 | |
| 0005515 | |
| 0005886 | |
| 0005901 | |
| 0006641 | |
| 0006897 | |
| 0008285 | |
| 0009968 | |
| 0016021 | |
| 0019217 | |
| 0019915 | |
| 0045019 | |
| 0045121 | |
| 0045907 | |
| 0045908 | |
| 0048471 | |
| 0051259 | |
| 0051260 | |
| 0000004 | |
| 0005198 | |
| 0005887 | |
| 0016599 |
| Alias | Cav |
|---|---|
| Eae10 | |
| Experimental Allergic Encephalomyelitis QTL 10 | |
| susceptibility to experimental allergic encephalomyelitis 10 | |
| caveolin caveolae protein 22 kDa | |
| Cav-1 | |
| caveolin, caveolae protein 1 | |
| 22 kDa | |
| caveolin 1 caveolae protein, 22kD | |
| caveolin 1 alpha | |
| caveolin, caveolae | |
| Caveolin, caveolae protein, 22 kDa | |
| 22 kDa caveolin 1 caveolae protein | |
| CAV1 | |
| CAV1_HUMAN | |
| caveolae protein, 22-kD | |
| caveolin 1 | |
| caveolin 1, alpha isoform | |
| caveolin 1, caveolae protein, 22kD | |
| VIP21 | |
| 22 kDa caveolin | |
| 22 kDa caveolae protein | |
| caveolin | |
| caveolin 1, beta isoform | |
| caveolin I | |
| caveolin 1, caveolae protein, 22kDa | |
| caveolin, caveolae protein | |
| CAV I |
| Organism | Mus musculus |
|---|---|
| Homo sapiens | |
| Rattus norvegicus | |
| Human |
| MedLine Reference | 11884617 |
|---|---|
| 12122055 | |
| 11865038 | |
| 1360410 | |
| 15219854 | |
| 10197531 | |
| 10373486 | |
| 10460238 | |
| 12388077 | |
| 12388596 | |
| 12466851 | |
| 12832401 | |
| 12927782 | |
| 15164767 | |
| 8552590 | |
| 9148942 | |
| 9685399 |
| LocusLink ID | 112389 |
|---|---|
| 12389 | |
| 25404 | |
| 116578 | |
| 857 |
| FunctionalClass | protein binding |
|---|---|
| structural molecule |
| RGD ID | 2280 |
|---|
| Hugo Symbol | CAV1 |
|---|
| Unigene ID | Rn.22518 |
|---|---|
| Mm.28278 | |
| Hs.74034 |
| Keyword | cytoplasm |
|---|
| GO Cellular Component | caveola |
|---|---|
| integral to membrane | |
| integral to membrane of membrane fraction | |
| lipid raft | |
| perinuclear region | |
| plasma membrane | |
| caveolar membrane | |
| integral to plasma membrane | |
| membrane fraction |
| GO Molecular Function | structural molecule activity |
|---|---|
| protein binding activity | |
| tumor suppressor | |
| protein binding |
| Cell Localization | Plasma membrane |
|---|
| Pathway | MAPK signaling |
|---|---|
| Integrin Signaling | |
| TNF-alpha | |
| LT-alpha | |
| CD40L | |
| AGT-LRP2 | |
| AREG-EGFR | |
| BDNF-NGFR | |
| BDNF-NTRK1 | |
| BTC-EGFR | |
| CSF1-IL6R | |
| CSF3-IL6R | |
| CYR61-ITGAV | |
| DTR-CD44 | |
| DTR-EGFR | |
| DTR-ERBB4 | |
| EGF-EGFR | |
| EGF-ERBB2 | |
| EGF-ERBB3 | |
| EGF-ERBB4 | |
| EGF-LRP8 | |
| EGF-NGFR | |
| EREG-EGFR | |
| F2-ITGAV | |
| F2-LRP1 | |
| F2-LRP2 | |
| F2-THBD | |
| FGF1-GPC1 | |
| FGF2-CD44 | |
| FGF2-FGFR1 | |
| FGF2-FGFR2 | |
| FGF2-FGFR3 | |
| FGF2-GPC1 | |
| FGF2-TGFBR3 | |
| FGF7-GPC1 | |
| GH1-IGF1R | |
| GRO1-EGFR | |
| IFNG-HLA-C | |
| IFNG-IFNGR1 | |
| IFNG-IFNGR2 | |
| IGF1-BST1 | |
| IGF1-IGF1R | |
| IGF1-IGF2R | |
| IGF1-LRP5 | |
| INS-EGFR | |
| INS-HLA-DRB1 | |
| INS-IGF1R | |
| INS-TFRC | |
| LTA-TNFRSF1B | |
| NGFB-NGFR | |
| NGFB-NTRK1 | |
| NGFB-NTRK2 | |
| NGFB-NTRK3 | |
| NRG1-EGFR | |
| NTF3-NGFR | |
| NTF3-NTRK1 | |
| NTF5-NGFR | |
| NTF5-NTRK1 | |
| PLG-PLAUR | |
| PRL-PRLR | |
| SLIT1-GPC1 | |
| SLIT2-GPC1 | |
| TGFA-EGFR | |
| THBS1-ITGB1 | |
| TNF-NGFR | |
| VEGF-CD44 | |
| VEGF-EGFR | |
| VEGF-FLT1 | |
| VEGF-FLT4 | |
| VEGF-GPC1 | |
| VEGF-IL1R1 | |
| VEGF-KDR | |
| PPAR all | |
| PPARgamma | |
| AR | |
| ERalpha | |
| NR common regulators |
| GO Biological Process | endocytosis |
|---|---|
| inactivation of MAPK | |
| lipid storage | |
| negative regulation of cell proliferation | |
| negative regulation of endothelial cell proliferation | |
| negative regulation of nitric oxide biosynthesis | |
| negative regulation of signal transduction | |
| negative regulation of vasodilation | |
| positive regulation of vasoconstriction | |
| protein homooligomerization | |
| protein oligomerization | |
| regulation of fatty acid metabolism | |
| triacylglycerol metabolism | |
| biological process unknown |
| State | 1 alpha isoform |
|---|---|
| 1 beta isoform |
| MGI ID | 102709 |
|---|---|
| 1309531 |
| Swiss-Prot Accession | Q03135 |
|---|
| OMIM ID | 601047 |
|---|---|
| 1309531 | |
| OMIM:601047 |
| Source | Curated |
|---|---|
| BIND | |
| ResNet |