| Name | FOXO1A |
|---|---|
| Description | forkhead box O1A (rhabdomyosarcoma) |
| Owner | Public |
| URN | urn:agi-llid:2308 |
| Connectivity | 65 |
| Notes | This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. |
| Hugo ID | 3819 |
| Microarray ID | A_43_P15648 |
|---|---|
| 106989_at | |
| 110271_at | |
| 1416981_at | |
| 1456529_at | |
| 162780_at | |
| A_51_P138044 | |
| AF032885 | |
| 202723_s_at | |
| 228484_s_at | |
| 40570_at | |
| 202724_s_at | |
| RC_AA609017_s_at | |
| U02310_at | |
| u36922_at | |
| A_23_P151426 | |
| A_14_P108536 | |
| A_14_P100972 | |
| A_14_P138465 | |
| A_14_P104811 | |
| A_24_P22079 | |
| 514 | |
| OH7783 |
| Chromosome position | 3 22.5 cM |
|---|---|
| 13q14.1 | |
| 2q26 |
| GO ID | 0003700 |
|---|---|
| 0005634 | |
| 0006350 | |
| 0006357 | |
| 0006916 | |
| 0001568 | |
| 0003677 | |
| 0005737 | |
| 0006355 | |
| 0008286 | |
| 0042127 |
| Alias | forkhead protein I |
|---|---|
| Fkhr1 | |
| forkhead box O1A (rhabdomyosarcoma) | |
| forkhead protein 1 | |
| Fkhr I | |
| FKH I | |
| Foxo I | |
| FKHR | |
| Forkhead related transcription factor | |
| forkhead homolog I | |
| forkhead homolog 1 | |
| similar to forkhead protein FKHR | |
| Afxh | |
| Forkhead in rhabdomyosarcoma | |
| forkhead, Drosophila, homolog of, in rhabdomyosarcoma | |
| FOX O1A | |
| Foxo1 | |
| FOXO1A | |
| homolog of Drosophila forkhead,, in rhabdomyosarcoma | |
| FKH1 | |
| forkhead (Drosophila) homolog 1 (rhabdomyosarcoma) | |
| forkhead box O1 | |
| forkhead box O1A | |
| forkhead homolog 1 (rhabdomyosarcoma) | |
| forkhead, , homolog of, in rhabdomyosarcoma | |
| forkhead protein FKHR |
| Organism | Human |
|---|---|
| Homo sapiens | |
| Rattus norvegicus | |
| Mus musculus |
| MedLine Reference | 10871843 |
|---|---|
| 7862145 | |
| 12488434 | |
| 12857750 | |
| 14978268 | |
| 15184386 | |
| 10960473 |
| LocusLink ID | 2308 |
|---|---|
| 99758 | |
| 56458 | |
| 84482 |
| FunctionalClass | DNA binding |
|---|---|
| transcription factor |
| RGD ID | 620283 |
|---|
| Hugo Symbol | FOXO1A |
|---|
| Unigene ID | Rn.116108 |
|---|---|
| Rn.102196 | |
| Hs.170133 | |
| Hs.370666 | |
| Mm.29891 |
| GO Cellular Component | nucleus |
|---|---|
| cytoplasm |
| Cell Localization | Nucleus |
|---|
| Pathway | AKT signaling |
|---|---|
| Insulin Receptor Signaling | |
| Apoptosis | |
| Mitochondrial control of Apoptosis | |
| Inhibition of Apoptosis | |
| NTRK1 -> FOXO1A signalling pathway | |
| ICAM2 -> FOXO1A signalling pathway | |
| IGF1R -> FOXO1A signalling pathway | |
| TNFRSF5 -> FOXO1A signalling pathway | |
| EGF-EGFR | |
| EGF-ERBB2 | |
| EGF-ERBB3 | |
| EGF-ERBB4 | |
| EGF-LRP8 | |
| EGF-NGFR | |
| HGF-CD44 | |
| HGF-FGFR2 | |
| HGF-IL6R | |
| HGF-MET | |
| IGF1-BST1 | |
| IGF1-IGF1R | |
| IGF1-IGF2R | |
| IGF1-LRP5 | |
| IL2-IL15RA | |
| IL2-IL2RA | |
| IL2-IL2RB | |
| IL2-IL2RG | |
| IL2-IL4R | |
| IL3-CD8A | |
| IL3-CSF2RB2 | |
| IL3-EPOR | |
| IL3-IL3RA | |
| IL6-IL6R | |
| IL6-IL6ST | |
| IL6-LIFR | |
| IL6-TNFRSF5 | |
| IL7-IL2RG | |
| IL7-IL7R | |
| INS-EGFR | |
| INS-HLA-DRB1 | |
| INS-IGF1R | |
| INS-TFRC | |
| NGFB-NGFR | |
| NGFB-NTRK1 | |
| NGFB-NTRK2 | |
| NGFB-NTRK3 | |
| TNFSF10-TNFRSF10A | |
| TNFSF10-TNFRSF10B | |
| TNFSF10-TNFRSF1A | |
| TNFSF10-TNFRSF6 | |
| TNFSF6-TNFRSF6 | |
| PXR | |
| PPAR all | |
| PPARgamma | |
| PGC1alpha | |
| AR | |
| ERalpha | |
| HNF4a | |
| NR common targets | |
| NR common regulators |
| GO Biological Process | cell growth and/or maintenance |
|---|---|
| regulation of transcription from Pol II promoter | |
| anti-apoptosis | |
| regulation of transcription from RNA polymerase II promoter | |
| transcription | |
| blood vessel development | |
| insulin receptor signaling pathway | |
| regulation of cell proliferation | |
| regulation of transcription, DNA-dependent |
| Group | Transcription factors |
|---|
| MGI ID | 1890077 |
|---|
| Swiss-Prot Accession | Q12778 |
|---|
| OMIM ID | 136533 |
|---|---|
| 268220 | |
| OMIM:136533 | |
| OMIM:268220 |
| Source | Curated |
|---|