| Name | MUC1 |
|---|---|
| Description | mucin 1, transmembrane |
| Owner | Public |
| URN | urn:agi-llid:4582 |
| Connectivity | 42 |
| Notes | CD227 (MUC1)is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of CD227 uses all seven exons and is a type 1 transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O-glycosylated and alterations in glycosylation have been shown in epithelial cancer cells [PROW] |
| Hugo ID | 7508 |
| Microarray ID | 38784_g_at |
|---|---|
| 38785_at | |
| 38783_at | |
| 207847_s_at | |
| 211695_x_at | |
| J05582_s_at | |
| M35093_s_at | |
| X52228_at | |
| 1083_s_at | |
| A_14_P134330 | |
| A_23_P137856 | |
| OR1964 | |
| OH2265 | |
| 102918_at | |
| 1449199_at | |
| m65132_s_at | |
| A_51_P467346 | |
| A_52_P58208 | |
| J05581 | |
| 213693_s_at |
| Chromosome position | 1q21 |
|---|---|
| 3 44.8 cM | |
| 2q34 |
| GO ID | 0005615 |
|---|---|
| 0005179 | |
| 0005576 | |
| 0016021 | |
| 0003779 | |
| 0005856 | |
| 0005887 |
| Alias | EMA |
|---|---|
| PEM | |
| Mucin 1 precursors | |
| Carcinoma-associated mucin | |
| DF3 antigen | |
| Tumor-associated mucin | |
| polymorphic epithelial mucin | |
| CD227 | |
| epithelial membrane antigen | |
| H23 antigen | |
| MUC1 | |
| Mucin 1 precursor | |
| peanut-reactive urinary mucin | |
| Tumor-associated epithelial membrane antigen | |
| Episialin | |
| H23AG | |
| mucin 1, transmembrane | |
| MUC I | |
| Breast carcinoma-associated antigen DF3 |
| Organism | Mus musculus |
|---|---|
| Homo sapiens | |
| Rattus norvegicus |
| MedLine Reference | 1697589 |
|---|---|
| 9623612 | |
| 12466851 |
| LocusLink ID | 24571 |
|---|---|
| 4582 | |
| 17829 |
| FunctionalClass | hormone |
|---|---|
| actin binding |
| RGD ID | 3122 |
|---|
| Hugo Symbol | MUC1 |
|---|
| Unigene ID | Rn.10779 |
|---|---|
| Hs.89603 | |
| Mm.16193 |
| GO Cellular Component | extracellular space |
|---|---|
| integral to membrane | |
| cytoskeleton | |
| integral to plasma membrane | |
| extracellular region |
| Cell Localization | Plasma membrane |
|---|
| Pathway | AREG-EGFR |
|---|---|
| BTC-EGFR | |
| DTR-EGFR | |
| DTR-ERBB4 | |
| EGF-ERBB2 | |
| EGF-ERBB3 | |
| EGF-ERBB4 | |
| EGF-LRP8 | |
| EGF-NGFR | |
| EREG-EGFR | |
| EREG-ERBB4 | |
| GRO1-EGFR | |
| IFNG-HLA-C | |
| IFNG-IFNGR1 | |
| IFNG-IFNGR2 | |
| IL2-IL15RA | |
| IL2-IL2RA | |
| IL2-IL2RB | |
| IL2-IL4R | |
| IL6-IL6R | |
| IL6-IL6ST | |
| IL6-LIFR | |
| IL6-TNFRSF5 | |
| INS-EGFR | |
| NRG1-CD44 | |
| NRG1-EGFR | |
| NRG1-ERBB2 | |
| NRG1-ERBB3 | |
| NRG1-ERBB4 | |
| NRG2-ERBB3 | |
| TGFA-EGFR | |
| TNF-IL15RA | |
| TNF-NGFR | |
| TNF-TNFRSF1B | |
| TNFSF11-TNFRSF11A | |
| TNFSF11-TNFRSF11B | |
| VEGF-EGFR | |
| PPAR all | |
| PPARgamma |
| MGI ID | 97231 |
|---|
| Swiss-Prot Accession | P15941 |
|---|
| OMIM ID | 158340 |
|---|
| Source | Curated |
|---|